A prospective study of periodontal disease and risk of rheumatoid arthritis.
A prospective study of periodontal disease and risk of rheumatoid arthritis.
复制标题
DOI：
10.3899/jrheum.091398
复制
发表时间：
2010-09
期刊：
影响因子：
--
通讯作者：
Costenbader KH
中科院分区：
文献类型：
--
作者：
Arkema EV;Karlson EW;Costenbader KH
在一个大的前瞻性队列中测试牙周病(PD)和类风湿性关节炎(RA)发病之间的关系。在护士健康研究前瞻性队列中，我们对81,132名女性的牙周手术史、牙齿脱落和类风湿性关节炎风险进行了前瞻性分析。牙周手术和牙齿缺失作为帕金森病病史的指标。1992年至2004年共确诊292例类风湿关节炎病例。对近两年的牙周手术和牙齿脱落情况进行问卷调查，收集时间为1992年。用COX比例风险模型评估年龄、吸烟、天然牙齿数、体重指数、产次、母乳喂养、绝经后状态、绝经后激素使用、父亲职业和饮酒等因素与牙周手术、牙齿脱落与类风湿关节炎风险的关系。在多变量调整模型中，与无牙周手术或牙齿脱落史的女性相比，接受牙周手术或牙齿缺失的女性患RA的风险没有显著增加(RR=1.24；95%CI(0.83，1.83)和RR=1.18；95%CI(0.47，2.95))。在按曾经吸烟者和从不吸烟者分层的分析中，曾经吸烟者接受牙周手术的风险增加，这也是不显著的。那些患有严重帕金森病(既有牙周手术史又有牙齿脱落史)的患者风险没有显著增加。在这一大群美国女性中，没有证据表明有牙周手术和/或牙齿脱落史的人患晚发型类风湿性关节炎的风险增加。
To test for an association between periodontal disease (PD) and incident rheumatoid arthritis (RA) in a large prospective cohort. We conducted a prospective analysis of history of periodontal surgery, tooth loss and risk of RA among 81,132 women in the Nurses’ Health Study prospective cohort. Periodontal surgery and tooth loss were used as proxies for history of PD. There were 292 incident RA cases diagnosed from 1992 to 2004. Information on periodontal surgery and tooth loss in the past two years was collected by questionnaire in 1992. Cox proportional hazards models were used to assess relationships between periodontal surgery, tooth loss and RA risk adjusting for age, smoking, number of natural teeth, BMI, parity, breastfeeding, postmenopausal status, postmenopausal hormone use, father’s occupation and alcohol intake. Compared with those who reported no history of periodontal surgery or tooth loss, women with periodontal surgery or tooth loss did not have a significantly elevated risk of RA in multivariable-adjusted models (RR=1.24; 95% CI (0.83, 1.83) and RR=1.18; 95% CI (0.47, 2.95), respectively). In analyses stratified by ever and never smokers, ever smokers with periodontal surgery had an increased risk that was also non-significant. Those with severe PD (both history of periodontal surgery and tooth loss) did not have a significant increased risk. In this large cohort of U.S. women, there is no evidence of an increased risk of later onset RA among those with a history of periodontal surgery and/or tooth loss.
登录
查看更多内容
影响因子：
4.3
作者：
Genco, Robert J.;Falkner, Karen L.;Trevisan, Maurizio
通讯作者：
Trevisan, Maurizio
影响因子：
5.5
作者：
HOCHBERG, MC;SPECTOR, TD
通讯作者：
SPECTOR, TD
牙龈卟啉单胞菌可能在牙周炎相关类风湿性关节炎的发病机制中发挥重要作用
影响因子：
4.7
作者：
Liao, Feng;Li, Zubing;Cheng, Xiangrong
通讯作者：
Cheng, Xiangrong
影响因子：
4.3
作者：
Bartold, PM;Marshall, RI;Haynes, DR
通讯作者：
Haynes, DR
DOI：
10.1111/j.1600-0528.1992.tb01702.x
发表时间：
1992-10-01
影响因子：
2.3
作者：
ARNEBERG, P;BJERTNESS, E;BJERKHOEL, F
通讯作者：
BJERKHOEL, F