ω-3 polyunsaturated fatty acid supplementation ameliorates lipopolysaccharide-induced behavioral deficits and modulates neurotrophic factors in rats: Focus on tPA/PAI-1 system and BDNF-TrkB signaling
ω-3 polyunsaturated fatty acid supplementation ameliorates lipopolysaccharide-induced behavioral deficits and modulates neurotrophic factors in rats: Focus on tPA/PAI-1 system and BDNF-TrkB signaling
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α-3 多不饱和脂肪酸补充剂可改善脂多糖诱导的行为缺陷并调节大鼠神经营养因子：关注 tPA/PAI-1 系统和 BDNF-TrkB 信号传导
DOI：
10.1016/j.jff.2017.01.010
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发表时间：
2017-03
影响因子：
5.6
通讯作者：
Pei Jiang
中科院分区：
文献类型：
--
作者：
Ruili Dang;Xueyuan Zhou;Pengfei Xu;Yujin Guo;Xiaoxue Gong;Shan Wang;Fang Yuan;Jia Yao;Pei Jiang
ω-3 PUFA具有神经营养作用，这与其抗抑郁特性有关。本研究发现，脂多糖（lipopolysaccharide，LPS）暴露可导致大鼠抑郁样状态，并引起神经营养网络的紊乱，ω-3 PUFA预处理可部分恢复这种紊乱。考虑到BDNF在抑郁症中的作用，我们进一步评估了前体和成熟BDNF以及proBDNF切割相关基因、组织型纤溶酶原激活物（tPA）和纤溶酶原激活物抑制剂-1（派-1）的表达。结果发现，补充ω-3 PUFA可诱导LPS处理大鼠tPA的表达，并抑制派-1的表达。虽然LPS对proBDNF表达没有影响，但它显著抑制BDNF成熟和TrkB活化。同时，ω-3 PUFA给药部分增强了炎症脑中的BDNF-TrkB信号传导。总的来说，我们的数据首先评估了ω-3 PUFA在炎症背景下的神经营养作用，突出了ω-3 PUFA的抗抑郁作用中tPA/派-1和BDNF-TrkB信号转导的参与。
ω-3 PUFA contains neurotrophic actions, which are associated with its antidepressant properties. In this study, we found that lipopolysaccharide (LPS) exposure induced the rats to a depression-like state and caused disturbances in neurotrophic network, which were partly restored by ω-3 PUFA pretreatment. Given the well-documented role of BDNF in depression, we further assessed the expression of precursor and mature BDNF and proBDNF cleavage-related genes, tissue plasmogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1). We found that ω-3 PUFA supplementation induced tPA and inhibited PAI-1 expression in the LPS-treated rats. While LPS had no effect on proBDNF expression, it markedly suppressed BDNF maturation and TrkB activation. Meanwhile, ω-3 PUFA administration partly enhanced BDNF-TrkB signaling in the inflamed brain. Collectively, our data firstly evaluated the neurotrophic action of ω-3 PUFA in the context of inflammation, highlighting the involvement of tPA/PAI-1 and BDNF-TrkB signaling in the antidepressant effects of ω-3 PUFA.
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DOI：
10.1017/s1461145712000053
发表时间：
2013-03
期刊：
The international journal of neuropsychopharmacology
影响因子：
--
作者：
M. Segawa;S. Morinobu;Tomoya Matsumoto;Manabu Fuchikami;S. Yamawaki
通讯作者：
M. Segawa;S. Morinobu;Tomoya Matsumoto;Manabu Fuchikami;S. Yamawaki
DOI：
10.2174/1871527311312040003
发表时间：
2013-06
期刊：
CNS & neurological disorders drug targets
影响因子：
--
作者：
Levant B
通讯作者：
Levant B
影响因子：
2.9
作者：
Mimi Tang;Pei Jiang;Huande Li;H. Cai;Yiping Liu;H. Gong;Lihong Zhang
通讯作者：
Mimi Tang;Pei Jiang;Huande Li;H. Cai;Yiping Liu;H. Gong;Lihong Zhang
影响因子：
3.7
作者：
Dianer Yang;Yu-Yo Sun;Niza Nemkul;Jessica M. Baumann;A. Shereen;R. Dunn;M. Wills-Karp;D. Lawrence;D. Lindquist;C. Kuan
通讯作者：
Dianer Yang;Yu-Yo Sun;Niza Nemkul;Jessica M. Baumann;A. Shereen;R. Dunn;M. Wills-Karp;D. Lawrence;D. Lindquist;C. Kuan
影响因子：
5.1
作者：
H. Ko;Sung Hoon Lee;Ki Chan Kim;So Hyun Joo;W. Choi;C. Shin
通讯作者：
H. Ko;Sung Hoon Lee;Ki Chan Kim;So Hyun Joo;W. Choi;C. Shin