N-3 (omega-3) polyunsaturated Fatty acids in the pathophysiology and treatment of depression: pre-clinical evidence.
N-3 (omega-3) polyunsaturated Fatty acids in the pathophysiology and treatment of depression: pre-clinical evidence.
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DOI：
10.2174/1871527311312040003
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发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Levant B
中科院分区：
文献类型：
--
作者：
Levant B
越来越多的文献表明，低组织水平和/或饮食摄入的n-多不饱和脂肪酸（PUFA）与抑郁症有关。动物研究表明，低组织和/或饮食n-3 PUFA可导致与抑郁症相关的行为和神经生物学效应，并可增强压力的后果。较高的n- 3 PUFA组织水平或摄入量具有相反的效果。这些数据支持n-3 PUFAs水平参与抑郁症的疾病过程。此外，这些临床前研究结果表明，n-3 PUFA可能有助于疾病的神经生物学机制，包括对多巴胺能和多巴胺能功能的控制，海马中脑源性神经营养因子（BDNF）的调节，下丘脑-垂体-肾上腺轴的调节，以及对神经炎症的影响。本文综述了n-3 PUFA在抑郁症的病理生理学和治疗中的作用的临床前证据。讨论了这些发现对未来临床前研究和临床应用的影响。
A growing literature suggests the association of low tissue levels and/or dietary intake of n-polyunsaturated fatty acids (PUFA) with depressive illnesses. Animal studies show that low tissue and/or dietary n-3 PUFAs can lead to behaviors and neurobiological effects associated with depression, and can potentiate the consequences of stress. Higher n- 3 PUFA tissue levels or intake have the opposite effect. These data support the involvement of n-3 PUFAs levels in the disease processes underlying depression. In addition, these pre-clinical findings indicate neurobiological mechanisms whereby n-3 PUFAs may contribute to the disease including control of serotonergic and dopaminergic function, modulation of brain-derived neurotrophic factor (BDNF) in the hippocampus, regulation of the hypothalamic-pituitary-adrenal axis, and effects on neuroinflammation. This pre-clinical evidence for a role for n-3 PUFA in the pathophysiology and treatment of depressive illness are reviewed. The implications of these finding for future pre-clinical research and clinical application are discussed.
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