Natural products in drug discovery: advances and opportunities.
Natural products in drug discovery: advances and opportunities.
复制标题
药物发现中的天然产物：进展与机遇。
DOI：
10.1038/s41573-020-00114-z
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Supuran CT
中科院分区：
文献类型：
--
作者：
Atanasov AG;Zotchev SB;Dirsch VM;International Natural Product Sciences Taskforce;Supuran CT
天然产物及其结构类似物在历史上对药物治疗做出了重大贡献，特别是对于癌症和传染病。然而，天然产品也对药物发现提出了挑战，例如筛选、分离、表征和优化方面的技术障碍，这导致制药业从1990年代起对天然产品的追求下降。近年来，一些技术和科学发展-包括改进的分析工具，基因组挖掘和工程策略，以及微生物培养的进步-正在应对这些挑战并开辟新的机遇。因此，人们对天然产品作为药物先导的兴趣正在恢复，特别是在解决抗菌素耐药性方面。在这里，我们总结了最近的技术发展，使基于天然产物的药物发现，突出选择的应用和讨论的关键机会。天然产物在历史上为药物治疗做出了重大贡献，但也为药物发现带来了挑战，例如筛选，分离，表征和优化的技术障碍。本综述讨论了最近的技术发展-包括改进的分析工具，基因组挖掘和工程策略，以及微生物培养的进步-这些技术发展使基于天然产物的药物发现得以振兴。
Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities. Natural products have historically made a major contribution to pharmacotherapy, but also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization. This Review discusses recent technological developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — that are enabling a revitalization of natural product-based drug discovery.
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影响因子：
21.8
作者：
Bozhueyuek, Kenan A. J.;Linck, Annabell;Bode, Helge B.
通讯作者：
Bode, Helge B.
影响因子：
2.1
作者：
Aligiannis, Nektarios;Halabalaki, Maria;Skaltsounis, Leandros A.
通讯作者：
Skaltsounis, Leandros A.
影响因子：
5.2
作者：
Anyaogu DC;Mortensen UH
通讯作者：
Mortensen UH
影响因子：
16
作者：
Atanasov AG;Waltenberger B;Pferschy-Wenzig EM;Linder T;Wawrosch C;Uhrin P;Temml V;Wang L;Schwaiger S;Heiss EH;Rollinger JM;Schuster D;Breuss JM;Bochkov V;Mihovilovic MD;Kopp B;Bauer R;Dirsch VM;Stuppner H
通讯作者：
Stuppner H
影响因子：
5.1
作者：
Bode, Edna;He, Yue;Bode, Helge B.
通讯作者：
Bode, Helge B.