Cell adhesion molecules regulating neurite growth from amacrine and rod photoreceptor cells [published erratum appears in J Neurosci 1994 Oct;14(10):following table of contents]
Cell adhesion molecules regulating neurite growth from amacrine and rod photoreceptor cells [published erratum appears in J Neurosci 1994 Oct;14(10):following table of contents]
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细胞粘附分子调节无长突和视杆感光细胞的神经突生长[已发表的勘误表出现在 J Neurosci 1994 年 Oct;14(10)：以下目录]
作者：
IJ Kljavin;C. Lagenaur;JL Bixby;T. Reh
细胞粘附分子（CAMs）负责促进神经节细胞轴突的生长，当它们从视网膜穿过视神经，最终到达大脑中的远处目标时，我们对细胞粘附分子（CAMs）已经了解了很多。然而，CAMs对于调节非投射神经元（如无突细胞和杆状细胞）轴突生长的重要作用尚不清楚。这种局部回路神经元将它们的神经突在神经节细胞轴突通常不会碰到的细胞表面上延伸相当短的距离。为了研究调节局部回路神经元轴突或树突生长的机制，我们在体外用免疫纯化的NCAM、L1和n -钙粘蛋白（在发育中的视网膜中发现的三种特征良好的粘附分子）检测了来自大鼠的无突细胞和杆状光感受器细胞的神经突生长。出生后早期（P3）或晚期（P10）无毛细胞在所有三种CAM上都长出了神经突，但对每种CAM有反应的无毛细胞的百分比有显著差异。没有CAMs支持出生后早期杆状体的神经突生长，但令人惊讶的是，NCAM刺激了出生后第10天分离的杆状体的神经突生长。出生后的神经节细胞也进行了比较，发现在NCAM上没有生长神经突，但在L1和N-钙粘蛋白上生长了广泛的突起。这些结果表明，NCAM、L1和n -钙粘蛋白可以促进局部回路神经元的神经突生长，但任何特定CAM的有效性取决于细胞类型和发育时期。
A great deal is now known about the cell adhesion molecules (CAMs) that are responsible for promoting the growth of ganglion cell axons as they project out of the retina through the optic nerve and finally to distant targets in the brain. However, the CAMs important for regulating axon outgrowth from nonprojection neurons, such as amacrine cells and rods, are not known. Such local circuit neurons extend their neurites rather short distances on cellular surfaces not normally encountered by the ganglion cell axons. To study the mechanisms regulating axon or dendrite growth from local circuit neurons, neurite outgrowth from amacrine cells and rod photoreceptor cells derived from the rat was examined in vitro on immunopurified forms of NCAM, L1, and N-cadherin, three well-characterized adhesive molecules found in the developing retina. Either early (P3) or late (P10) postnatal amacrine cells grew neurites on all three CAMs, but there were significant differences in the percentage of the amacrine cells that responded to each CAM. None of the CAMs supported neurite outgrowth from early postnatal rods, but, surprisingly, NCAM stimulated vigorous neurite extension from rods isolated at postnatal day 10. Postnatal ganglion cells were also examined for comparison and were found not to grow neurites on NCAM, but did grow extensive processes on L1 and N- cadherin. These results show that NCAM, L1, and N-cadherin can promote neurite outgrowth from local circuit neurons, but that the effectiveness of any particular CAM is dependent on the cell type and the developmental period.
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通过基质结合的粘附分子调节生长锥形态。
影响因子：
--
作者：
Payne,HR;Burden,SM;Lemmon,V
通讯作者：
Lemmon,V
DOI：
10.1073/pnas.83.24.9822
发表时间：
1986-12-01
影响因子：
11.1
作者：
HEMPERLY, JJ;EDELMAN, GM;CUNNINGHAM, BA
通讯作者：
CUNNINGHAM, BA
DOI：
10.1002/neu.480230311
发表时间：
1992-04-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
SNOW, DM;LETOURNEAU, PC
通讯作者：
LETOURNEAU, PC
硫酸软骨素蛋白多糖可能影响视网膜神经节细胞生长的方向。
DOI：
10.1242/dev.113.4.1473
发表时间：
1991
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Snow,DM;Watanabe,M;Letourneau,PC;Silver,J
通讯作者：
Silver,J
影响因子：
2.7
作者：
DRAZBA, J;LEMMON, V
通讯作者：
LEMMON, V