Secondary Complement Deficiency Impairs Anti-Microbial Immunity to Klebsiella pneumoniae and Staphylococcus aureus During Severe Acute COVID-19.
Secondary Complement Deficiency Impairs Anti-Microbial Immunity to Klebsiella pneumoniae and Staphylococcus aureus During Severe Acute COVID-19.
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DOI：
10.3389/fimmu.2022.841759
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
在严重COVID-19患者中观察到继发性肺炎克雷伯菌和金黄色葡萄球菌感染的高发病率。这种感染倾向的原因尚不清楚。我们的数据表明，急性COVID-19患者的补体消耗表现为C3、C4水平低和溶血活性丧失。鉴于革兰氏阴性菌的消除部分取决于补体介导的裂解，我们假设继发性低补体血症使抗体依赖性经典途径活化失活并损害血清杀菌活性（SBA）。研究了217名严重COVID-19患者。142例患者继发细菌感染。克雷伯菌属是最常见的革兰阴性菌，共检出58例，而沙门氏菌属为最常见的革兰阴性菌。金黄色葡萄球菌是22例患者中发现的主要革兰氏阳性菌。在急性重症COVID-19患者中观察到低补体血症，但在出院后三个月的康复期幸存者中未观察到。来自急性COVID-19患者的血清不能调理K。pneumoniae或S.金黄色葡萄球菌，并具有受损的补体介导的克雷伯氏菌的杀伤。我们得出结论，急性COVID-19期间补体过度活化导致继发性低补体血症，并易于发生机会性感染。
A high incidence of secondary Klebsiella pneumoniae and Staphylococcus aureus infection were observed in patients with severe COVID-19. The cause of this predisposition to infection is unclear. Our data demonstrate consumption of complement in acute COVID-19 patients reflected by low levels of C3, C4, and loss of haemolytic activity. Given that the elimination of Gram-negative bacteria depends in part on complement-mediated lysis, we hypothesised that secondary hypocomplementaemia is rendering the antibody-dependent classical pathway activation inactive and compromises serum bactericidal activity (SBA). 217 patients with severe COVID-19 were studied. 142 patients suffered secondary bacterial infections. Klebsiella species were the most common Gram-negative organism, found in 58 patients, while S. aureus was the dominant Gram-positive organism found in 22 patients. Hypocomplementaemia was observed in patients with acute severe COVID-19 but not in convalescent survivors three months after discharge. Sera from patients with acute COVID-19 were unable to opsonise either K. pneumoniae or S. aureus and had impaired complement-mediated killing of Klebsiella. We conclude that hyperactivation of complement during acute COVID-19 leads to secondary hypocomplementaemia and predisposes to opportunistic infections.
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DOI：
10.3390/pathogens10111426
发表时间：
2021-11-04
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
Emeraud C;Figueiredo S;Bonnin RA;Khecharem M;Ouzani S;Leblanc PE;Jousset AB;Fortineau N;Duranteau J;Dortet L
通讯作者：
Dortet L
影响因子：
4.2
作者：
Cusumano JA;Dupper AC;Malik Y;Gavioli EM;Banga J;Berbel Caban A;Nadkarni D;Obla A;Vasa CV;Mazo D;Altman DR
通讯作者：
Altman DR
影响因子：
7.3
作者：
Defendi F;Leroy C;Epaulard O;Clavarino G;Vilotitch A;Le Marechal M;Jacob MC;Raskovalova T;Pernollet M;Le Gouellec A;Bosson JL;Poignard P;Roustit M;Thielens N;Dumestre-Pérard C;Cesbron JY
通讯作者：
Cesbron JY
影响因子：
9.1
作者：
Bousfiha A;Jeddane L;Picard C;Ailal F;Bobby Gaspar H;Al-Herz W;Chatila T;Crow YJ;Cunningham-Rundles C;Etzioni A;Franco JL;Holland SM;Klein C;Morio T;Ochs HD;Oksenhendler E;Puck J;Tang MLK;Tangye SG;Torgerson TR;Casanova JL;Sullivan KE
通讯作者：
Sullivan KE
DOI：
10.1186/s41479-021-00083-w
发表时间：
2021-04-25
期刊：
Pneumonia (Nathan Qld.)
影响因子：
--
作者：
Feldman C;Anderson R
通讯作者：
Anderson R