Replication of putative susceptibility loci from genome-wide association studies associated with coronary atherosclerosis in Chinese Han population.
Replication of putative susceptibility loci from genome-wide association studies associated with coronary atherosclerosis in Chinese Han population.
复制标题
中国汉族人群冠状动脉粥样硬化相关全基因组关联研究推定易感位点的复制
DOI：
10.1371/journal.pone.0020833
复制
发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Huang W
中科院分区：
文献类型：
--
作者：
Xie F;Chu X;Wu H;Sun W;Shen M;Yang L;Wang Y;Wang Y;Shi J;Huang W
冠状动脉粥样硬化是心血管疾病的主要病因，是一种进展性疾病。近期的全基因组关联研究（GWAS）发现了几个与冠状动脉疾病（CAD）或其主要并发症心肌梗死（MI）相关的新位点。在本研究中，我们调查了先前报道的与CAD和MI相关的变异体与中国汉族人群冠状动脉粥样硬化之间的关联。
我们对来自中国的2335例冠状动脉粥样硬化患者和1078例接受冠状动脉造影的对照者进行了病例 - 对照关联研究。对位于1p13.3、1q41、2q36.3、6q25.1、9p21.3、10q11.21和15q22.33的14个单核苷酸多态性（SNP）在我们的样本集中进行了基因分型。9p21的6个SNP与冠状动脉粥样硬化易感性相关（趋势P < 0.05），其中rs10757274相关性最为显著（P = 2.38×10⁻⁸，比值比OR = 1.34）。在经过多重比较校正后，这些相关性仍然显著。1q41的rs17465637（趋势P = 6.83×10⁻³，OR = 0.86）也显示与冠状动脉粥样硬化显著相关，但在多重比较后相关性不显著。此外，10q11.21的rs501120（P = 8.36×10⁻³，OR = 0.80）在女性中与冠状动脉粥样硬化相关，但在男性和所有参与者中未显示相关性。在我们的数据中，1p13.3、2q36.3、6q25.1和15q22.33的变异体与冠状动脉粥样硬化和主要心血管危险因素无相关性。
我们的研究结果表明，9p21的变异体与中国汉族人群的冠状动脉粥样硬化显著相关。1q41的变异体显示出相关的提示性证据，10q11.21的变异体在女性中显示出相关的提示性证据，这需要在更大的样本中进一步研究。
Background Coronary atherosclerosis, the main cause of cardiovascular disease, is a progressive disease. Recent Genome Wide Association Studies (GWASs) discovered several novel loci associated with coronary artery disease (CAD) or its main complication myocardial infarction (MI). In this study, we investigated the associations between previously reported CAD- and MI-associated variants and coronary atherosclerosis in Chinese Han population. Methodology/Principal Findings We performed a case-control association study with 2,335 coronary atherosclerosis patients and 1,078 controls undergoing coronary angiography of Chinese Han from China. Fourteen single nucleotide polymorphisms (SNPs), located at 1p13.3, 1q41, 2q36.3, 6q25.1, 9p21.3, 10q11.21 and 15q22.33, were genotyped in our sample collection. Six SNPs at 9p21 were associated with coronary atherosclerosis susceptibility (Ptrend<0.05) and rs10757274 showed the most significant association (P = 2.38×10−08, OR = 1.34). These associations remained significant after adjustment for multiple comparisons. Rs17465637 at 1q41 (Ptrend = 6.83×10−03, OR = 0.86) also showed significant association with coronary atherosclerosis, but the association was not significant after multiple comparisons. Additionally, rs501120 (P = 8.36×10−03, OR = 0.80) at 10q11.21 was associated with coronary atherosclerosis in females, but did not show association in males and all participants. Variants at 1p13.3, 2q36.3, 6q25.1 and 15q22.33 showed no associations with coronary atherosclerosis and main cardiovascular risk factors in our data. Conclusions/Significance Our findings indicated variants at 9p21 were significantly associated with coronary atherosclerosis in Han Chinese. Variants at 1q41 showed suggestive evidence of association and variants at 10q11.21 showed suggestive evidence of association in females, which warrant further study in a larger sample.
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冠状动脉疾病的新遗传基因座的大规模关联分析。
DOI：
10.1161/atvbaha.108.181388
发表时间：
2009-05
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Coronary Artery Disease Consortium;Samani NJ;Deloukas P;Erdmann J;Hengstenberg C;Kuulasmaa K;McGinnis R;Schunkert H;Soranzo N;Thompson J;Tiret L;Ziegler A
通讯作者：
Ziegler A
与人类血液低密度脂蛋白胆固醇、高密度脂蛋白胆固醇或甘油三酯相关的六个新位点。
影响因子：
30.8
作者：
Kathiresan, Sekar;Melander, Olle;Guiducci, Candace;Surti, Aarti;Burtt, Noel P.;Rieder, Mark J.;Cooper, Gregory M.;Roos, Charlotta;Voight, Benjamin F.;Havulinna, Aki S.;Wahlstrand, Bjorn;Hedner, Thomas;Corella, Dolores;Tai, E. Shyong;Ordovas, Jose M.;Berglund, Goran;Vartiainen, Erkki;Jousilahti, Pekka;Hedblad, Bo;Taskinen, Marja-Riitta;Newton-Cheh, Christopher;Salomaa, Veikko;Peltonen, Leena;Groop, Leif;Altshuler, David M.;Orho-Melander, Marju
通讯作者：
Orho-Melander, Marju
影响因子：
30.8
作者：
Helgadottir, Anna;Thorleifsson, Gudmar;Stefansson, Kari
通讯作者：
Stefansson, Kari
影响因子：
15.9
作者：
ISHIBASHI, S;BROWN, MS;HERZ, J
通讯作者：
HERZ, J
影响因子：
1.2
作者：
Bosserhoff, AK;Moser, M;Buettner, R
通讯作者：
Buettner, R