Indoor environmental exposures and exacerbation of asthma: an update to the 2000 review by the Institute of Medicine.
Indoor environmental exposures and exacerbation of asthma: an update to the 2000 review by the Institute of Medicine.
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DOI：
10.1289/ehp.1307922
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发表时间：
2015-01
影响因子：
10.4
通讯作者：
Phipatanakul W
中科院分区：
文献类型：
--
作者：
Kanchongkittiphon W;Mendell MJ;Gaffin JM;Wang G;Phipatanakul W
背景：先前的研究已经发现特定的室内环境暴露与哮喘恶化之间的关系。目的：在这篇综述中，我们从室内暴露和哮喘恶化的科学文献中提供了最新的知识总结。方法：通过PubMed、参考文献列表和作者档案对2000年至2013年发表的关于室内暴露与哮喘加重的同行评议文章进行筛选。选择那些关注可改变的室内暴露与哮喘发作频率或严重程度的关系的文章进行综述。考虑到证据的强度，对研究结果进行了回顾和总结。结果：纳入69篇符合条件的文章。主要的改变结论包括：与室内湿气或与湿气有关的因子（儿童）的加重有因果关系；与湿气或湿气相关因子（成人）、内毒素和环境烟草烟雾（学龄前儿童）加重的关系；与室内可培养青霉菌或总真菌、二氧化氮、啮齿动物（非职业）、羽毛/羽绒枕头（相对于合成床上用品的保护性）以及（不考虑特定致敏性）尘螨、蟑螂、狗和与潮湿有关的病原体的恶化有关的有限或暗含证据。讨论：本综述纳入了自2000年以来报告的证据，增加了将许多室内因素与哮喘恶化联系起来的证据的强度。在对所有现有证据进行更彻底的审查之前，结论应被视为临时结论。结论：多次室内暴露，特别是与潮湿有关的因素，值得更多的关注，以防止哮喘恶化，甚至可能在非敏感个体。需要对这些和其他室内暴露进行进一步研究，以确定因果关系并评估干预措施。引用本文：Kanchongkittiphon W， Mendell MJ, Gaffin JM, Wang G, Phipatanakul W. 2015。室内环境暴露与哮喘恶化：医学研究所2000年综述的更新。环境卫生展望123:6-20；http://dx.doi.org/10.1289/ehp.1307922
Background: Previous research has found relationships between specific indoor environmental exposures and exacerbation of asthma. Objectives: In this review we provide an updated summary of knowledge from the scientific literature on indoor exposures and exacerbation of asthma. Methods: Peer-reviewed articles published from 2000 to 2013 on indoor exposures and exacerbation of asthma were identified through PubMed, from reference lists, and from authors’ files. Articles that focused on modifiable indoor exposures in relation to frequency or severity of exacerbation of asthma were selected for review. Research findings were reviewed and summarized with consideration of the strength of the evidence. Results: Sixty-nine eligible articles were included. Major changed conclusions include a causal relationship with exacerbation for indoor dampness or dampness-related agents (in children); associations with exacerbation for dampness or dampness-related agents (in adults), endotoxin, and environmental tobacco smoke (in preschool children); and limited or suggestive evidence for association with exacerbation for indoor culturable Penicillium or total fungi, nitrogen dioxide, rodents (nonoccupational), feather/down pillows (protective relative to synthetic bedding), and (regardless of specific sensitization) dust mite, cockroach, dog, and dampness-related agents. Discussion: This review, incorporating evidence reported since 2000, increases the strength of evidence linking many indoor factors to the exacerbation of asthma. Conclusions should be considered provisional until all available evidence is examined more thoroughly. Conclusion: Multiple indoor exposures, especially dampness-related agents, merit increased attention to prevent exacerbation of asthma, possibly even in nonsensitized individuals. Additional research to establish causality and evaluate interventions is needed for these and other indoor exposures. Citation: Kanchongkittiphon W, Mendell MJ, Gaffin JM, Wang G, Phipatanakul W. 2015. Indoor environmental exposures and exacerbation of asthma: an update to the 2000 review by the Institute of Medicine. Environ Health Perspect 123:6–20; http://dx.doi.org/10.1289/ehp.1307922
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