Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens.
Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens.
复制标题
DOI：
10.1126/science.aay6485
复制
发表时间：
2019-11-01
期刊：
影响因子：
--
通讯作者：
Elledge SJ
中科院分区：
文献类型：
--
作者：
Mina MJ;Kula T;Leng Y;Li M;de Vries RD;Knip M;Siljander H;Rewers M;Choy DF;Wilson MS;Larman HB;Nelson AN;Griffin DE;de Swart RL;Elledge SJ
麻疹病毒每年直接导致10万多人死亡。流行病学研究已将麻疹与感染后数年内发病率和死亡率增加联系起来，但其原因尚不清楚。麻疹病毒感染免疫细胞，引起急性免疫抑制。为了确定和量化麻疹对免疫系统的长期影响，我们使用了VirScan，一种追踪血液中数千种病原体表位抗体的检测方法。我们研究了77名在自然麻疹病毒感染前和感染后2个月未接种疫苗的儿童。麻疹导致个体中11%至73%的抗体库被消除。自然再暴露于病原体后检测抗体恢复。值得注意的是，在接种MMR（麻疹、腮腺炎和风疹）疫苗的婴儿中没有观察到这些免疫系统效应，但在麻疹感染的猕猴中得到了证实。麻疹感染后体液免疫记忆的减少产生对未来感染的潜在脆弱性，强调需要广泛接种疫苗。
Measles virus is directly responsible for more than 100,000 deaths yearly. Epidemiological studies have associated measles with increased morbidity and mortality for years after infection, but the reasons why are poorly understood. Measles virus infects immune cells, causing acute immune suppression. To identify and quantify long-term effects of measles on the immune system, we used VirScan, an assay that tracks antibodies to thousands of pathogen epitopes in blood. We studied 77 unvaccinated children before and 2 months after natural measles virus infection. Measles caused elimination of 11 to 73% of the antibody repertoire across individuals. Recovery of antibodies was detected after natural reexposure to pathogens. Notably, these immune system effects were not observed in infants vaccinated against MMR (measles, mumps, and rubella), but were confirmed in measles-infected macaques. The reduction in humoral immune memory after measles infection generates potential vulnerability to future infections, underscoring the need for widespread vaccination.
登录
查看更多内容
影响因子：
8.7
作者：
Griffin DE
通讯作者：
Griffin DE
流感在呼吸细菌疾病的严重程度和传播中的作用。
DOI：
10.1016/s2213-2600(14)70131-6
发表时间：
2014-09
期刊：
The Lancet. Respiratory medicine
影响因子：
--
作者：
Mina MJ;Klugman KP
通讯作者：
Klugman KP
影响因子：
6.4
作者：
Mina MJ;McCullers JA;Klugman KP
通讯作者：
Klugman KP
影响因子：
4.4
作者：
De Salort, Jose;Sintes, Jordi;Engel, Pablo
通讯作者：
Engel, Pablo
影响因子：
4.4
作者：
Hinton, PR;Xiong, JM;Tsurushita, N
通讯作者：
Tsurushita, N