Risk of breast cancer with progestins in combination with estrogen as hormone replacement therapy.
Risk of breast cancer with progestins in combination with estrogen as hormone replacement therapy.
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孕激素与雌激素联合作为激素替代疗法有患乳腺癌的风险。
DOI：
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发表时间：
2001
影响因子：
5.8
通讯作者：
G. Petroni
中科院分区：
文献类型：
--
作者：
R. Santen;J. Pinkerton;Christopher R McCartney;G. Petroni
Two recent studies have suggested that progestins substantially increase the relative risk (RR) of breast cancer when added to estrogens as hormone replacement therapy (HRT) (1-2). If correct this information could substantially change clinical practice. Here we review biological epidemiological and clinical data regarding the effects of progestins on the breast. From this analysis we conclude that no definitive proof exists to establish a causal relationship between progestins and breast cancer risk. However a wide range of biological and clinical data provides strong supportive evidence of such an effect. Based on this we believe that it is prudent to inform patients that progestin use may add to the increased risk imparted by estrogens. Patients should understand however that this increased risk is small particularly when associated with the short-term use of HRT. (excerpt)
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DOI：
10.1210/mend.13.6.0290
发表时间：
1999
期刊：
Molecular endocrinology (Baltimore, Md.)
影响因子：
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作者：
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Horwitz,KB
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DOI：
10.1016/0925-4439(91)90056-f
发表时间：
1991
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Moore,MR;Hathaway,LD;Bircher,JA
通讯作者：
Bircher,JA
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影响因子：
5
作者：
Risch,HA;Howe,GR
通讯作者：
Howe,GR
影响因子：
158.5
作者：
Grodstein, F;Stampfer, MJ;Hennekens, CH
通讯作者：
Hennekens, CH
影响因子：
10.3
作者：
Hankinson, SE;Willett, WC;Speizer, FE
通讯作者：
Speizer, FE