Linkage control between molecular and supramolecular chirality in 2₁-helical hydrogen-bonded networks using achiral components.
Linkage control between molecular and supramolecular chirality in 2₁-helical hydrogen-bonded networks using achiral components.
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DOI：
10.1038/ncomms2756
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发表时间：
2013
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
手性分子优先形成反映分子绝对构型的单手超分子组装体。然而，在特定的条件下，相反的手超分子组装体也获得，因为在键长的灵活性和非共价相互作用的可逆性。利手性选择性或转换现象的机制仍然不明确，大多数现象是偶然观察到的。在这里，我们证明了手性氢键的双重螺旋组装控制手性结晶状态的基础上，晶体学研究的建设。详细的研究所获得的晶体结构，使我们能够澄清的机制，并成功地利用非手性因子控制的超分子手性的手。这项研究清楚地揭示了在结晶状态下分子手性和超分子手性之间的联系。 手性分子形成单手的超分子组装体，但也可能被诱导切换到另一个手组装体，尽管驱动这些过程的机制尚不清楚。在这里，作者证明了通过引入非手性反离子的超分子组装手性的控制。
Chiral molecules preferentially form one-handed supramolecular assemblies that reflect the absolute configuration of the molecules. Under specific conditions, however, the opposite-handed supramolecular assemblies are also obtained because of flexibility in the bond length and reversibility of non-covalent interactions. The mechanism of the handedness selectivity or switching phenomenon remains ambiguous, and most phenomena are observed by chance. Here we demonstrate the construction of chiral hydrogen-bonded twofold helical assemblies with controlled handedness in the crystalline state based on crystallographic studies. Detailed investigation of the obtained crystal structures enabled us to clarify the mechanism, and the handedness of the supramolecular chirality was successfully controlled by exploiting achiral factors. This study clearly reveals a connection between molecular chirality and supramolecular chirality in the crystalline state. Chiral molecules form one-handed supramolecular assemblies but may be induced to switch to the other handed assembly, although the mechanisms driving these processes are unclear. Here, the authors demonstrate control of the supramolecular assembly handedness via the introduction of achiral counter ions.
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影响因子：
15
作者：
Kinbara, K;Hashimoto, Y;Saigo, K
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