Targeting p53 as a general tumor antigen.
Targeting p53 as a general tumor antigen.
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将 p53 作为一般肿瘤抗原。
DOI：
10.1073/pnas.92.26.11993
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发表时间：
1995
影响因子：
11.1
通讯作者：
Sherman,LA
中科院分区：
文献类型：
--
作者：
Theobald,M;Biggs,J;Dittmer,D;Levine,AJ;Sherman,LA
设计癌症免疫治疗剂和疫苗的主要障碍是许多肿瘤抗原的特异质性质和T细胞可能耐受广泛分布的抗原的可能性。我们设计了一种实验策略，利用蛋白质序列的物种差异来规避高亲和力T细胞的耐受性。使用HLA转基因小鼠获得对来自与HLA-A2.1相关的人p53肿瘤抑制分子的肽特异的细胞毒性T淋巴细胞。虽然这种p53特异性细胞毒性T细胞不识别非转化的人类细胞，但它们能够裂解各种各样的人类肿瘤细胞系，从而证实了广泛分布的决定簇的存在，这些决定簇可以作为免疫治疗的靶点。
A major barrier to the design of immunotherapeutics and vaccines for cancer is the idiosyncratic nature of many tumor antigens and the possibility that T cells may be tolerant of broadly distributed antigens. We have devised an experimental strategy that exploits species differences in protein sequences to circumvent tolerance of high-affinity T cells. HLA transgenic mice were used to obtain cytotoxic T lymphocytes specific for peptides from the human p53 tumor-suppressor molecule presented in association with HLA-A2.1. Although such p53-specific cytotoxic T cells did not recognize nontransformed human cells, they were able to lyse a wide variety of human tumor cells lines, thus confirming the existence of broadly distributed determinants that may serve as targets for immunotherapy.
影响因子：
5.4
作者：
HOUBIERS, JGA;NIJMAN, HW;MELIEF, CJM
通讯作者：
MELIEF, CJM
生长停滞的 MCF-7 细胞血清刺激后蛋白质合成 - p53 蛋白依赖性胞质易位
影响因子：
4.6
作者：
Kazuhide Takahashi;H. Sumimoto;Katsuo Suzuki;T. Ono
通讯作者：
T. Ono