Genomic characterization of colitis-associated colorectal cancer.
Genomic characterization of colitis-associated colorectal cancer.
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DOI：
10.1186/s12957-018-1428-0
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发表时间：
2018-07-02
影响因子：
3.2
通讯作者：
Wakai T
中科院分区：
文献类型：
--
作者：
Kameyama H;Nagahashi M;Shimada Y;Tajima Y;Ichikawa H;Nakano M;Sakata J;Kobayashi T;Narayanan S;Takabe K;Wakai T
炎症性肠病（IBD），包括溃疡性结肠炎（UC）和克罗恩病（CD），是一种慢性、特发性、反复的炎症性疾病。在IBD患者中发生的结直肠癌（CRC）被称为结肠炎相关结直肠癌（CAC），但潜在的致癌机制尚不清楚。基于下一代测序（NGS）数据，散发性结直肠癌的基因组分析已经得到了很好的描述。使用NGS，我们比较了日本和美国结直肠癌患者的415个癌症相关基因的所有外显子，并在两个人群中发现了相似的基因组改变模式。然而，对CAC的基因组分析尚未进行彻底的研究。CAC的分子发病机制与散发性结直肠癌有许多共同的特点，但在一些改变的时间和频率上有明显的差异。基因改变在CAC逐渐被阐明使用基因组测序分析。一些研究表明，UC和CD的基因改变模式不同。CAC的癌变取决于独特的环境、遗传和免疫因素。在这篇综述中，我们讨论了散发性结直肠癌和CAC之间基因组改变的差异。IBD患者的NGS有可能发现早期CAC并建议治疗靶点。
Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD), is a chronic, idiopathic, repeated inflammatory disease. Colorectal cancer (CRC) that develops in patients with IBD is known as colitis-associated colorectal cancer (CAC), but the underlying carcinogenic mechanism remains unclear. Genomic analysis of sporadic CRC has been well described based on next-generation sequencing (NGS) data. Using NGS, we compared all exons of 415 cancer-associated genes in patients in Japan and the USA who had CRC and found similar genomic alteration patterns among the two populations. However, genomic analysis of CAC has not been thoroughly investigated. The molecular pathogenesis of CAC shares many features with sporadic CRC, but there are distinct variations in the time and frequency of some alterations. Gene alterations in CAC are gradually being elucidated using genomic sequencing analyses. Some studies have shown that gene alteration patterns differ between UC and CD. The carcinogenesis of CAC depends on unique environmental, genetic, and immunological factors. In this review, we have discussed the differences in genomic alterations between sporadic CRC and CAC. NGS in patients with IBD has the potential to detect early CAC and to suggest therapeutic targets.
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影响因子：
8.8
作者：
通讯作者：
--
影响因子：
50.3
作者：
Grivennikov S;Karin E;Terzic J;Mucida D;Yu GY;Vallabhapurapu S;Scheller J;Rose-John S;Cheroutre H;Eckmann L;Karin M
通讯作者：
Karin M
DOI：
10.1016/j.cgh.2016.11.025
发表时间：
2017-05
期刊：
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
影响因子：
--
作者：
Fumery M;Dulai PS;Gupta S;Prokop LJ;Ramamoorthy S;Sandborn WJ;Singh S
通讯作者：
Singh S
影响因子：
24.5
作者：
CHOI, PM;ZELIG, MP
通讯作者：
ZELIG, MP
影响因子：
2.5
作者：
Kimura, Hideaki;Takahashi, Kenichi;Ozawa, Heita
通讯作者：
Ozawa, Heita