The role of organic proteins on the crack growth resistance of human enamel.
The role of organic proteins on the crack growth resistance of human enamel.
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DOI：
10.1016/j.actbio.2015.03.011
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发表时间：
2015-06
影响因子：
9.7
通讯作者：
Arola, Dwayne
中科院分区：
文献类型：
--
作者：
Yahyazadehfar, Mobin;Arola, Dwayne
牙釉质只有1%的蛋白质重量，是哺乳动物中矿化程度最高的组织。这项研究的重点是评估蛋白质对这种独特结构材料的抗断裂性的贡献。从人磨牙尖牙尖切取釉质切片，用常规断裂力学方法结合互补有限元分析对裂纹扩展阻力进行量化。在选定的样本中，使用氢氧化钾处理提取蛋白质。与完全蛋白化的对照相比，去除蛋白质会导致断裂韧性降低约40%。有机成分的损失对外在增韧机制最为不利，使其对断裂总能的贡献降低了80%以上。这种退化是由于未断裂的桥接韧带的脆化和随之而来的裂缝闭合应力的降低而发生的。虽然牙釉质的有机含量很少，但通过促进完整韧带的形成和增强其效力，裂纹生长增韧是必不可少的。有机成分的复制功能将是成功开发设计用于抗断裂的仿生材料的关键。
With only 1% protein by weight, tooth enamel is the most highly mineralized tissue in mammals. The focus of this study was to evaluate contributions of the proteins on the fracture resistance of this unique structural material. Sections of enamel were obtained from the cusps of human molars and the crack growth resistance was quantified using a conventional fracture mechanics approach with complementary finite element analysis. In selected specimens the proteins were extracted using a potassium hydroxide treatment. Removal of the proteins resulted in approximately 40% decrease in the fracture toughness with respect to the fully proteinized control. The loss of organic content was most detrimental to the extrinsic toughening mechanisms, causing over 80% reduction in their contribution to the total energy to fracture. This degradation occurred by embrittlement of the unbroken bridging ligaments and consequent reduction in the crack closure stress. Although the organic content of tooth enamel is very small, it is essential to crack growth toughening by facilitating the formation of unbroken ligaments and in fortifying their potency. Replicating functions of the organic content will be critical to the successful development of bio-inspired materials that are designed for fracture resistance.
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