Animal models for disc degeneration-an update.
Animal models for disc degeneration-an update.
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DOI：
10.14670/hh-11-910
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发表时间：
2018-06
影响因子：
2
通讯作者：
Li XJ
中科院分区：
文献类型：
--
作者：
Jin L;Balian G;Li XJ
椎间盘退变被认为是背痛的主要原因，给社会带来沉重负担，这既是因为它对个人生理的影响，也是因为它对世界经济的后果。在过去的几十年中，临床前的研究结果已经导致对椎间盘退变的理解显著增加，尽管该疾病的许多方面仍然不清楚。本综述的目的是总结现有的椎间盘退变研究的动物模型和使用这些模型的困难。对损伤以及环境因素导致的细胞和分子事件的坚定理解可能有助于开发治疗椎间盘退变的靶向疗法。
Intervertebral disc degeneration is considered a major cause of back pain that places a heavy burden on society, both because of its effect on the physiology of individuals and its consequences on the world economy. During the past few decades, research findings in the pre-clinical setting have led to a significant increase in the understanding of intervertebral disc degeneration, although many aspects of the disease remain unclear. The goal of this review is to summarize existing animal models for disc degeneration studies and the difficulties that are associated with the use of such models. A firm understanding of the cellular and molecular events that ensue as a result of injuries, as well as environmental factors, could be instrumental in the development of targeted therapies for the treatment of intervertebral disc degeneration.
两种细胞因子抑制剂的组合比单独使用每个抑制剂降低了核核诱导的神经损伤。
DOI：
10.2174/1874325001105010151
发表时间：
2011-04-28
期刊：
The open orthopaedics journal
影响因子：
--
作者：
Olmarker K
通讯作者：
Olmarker K