Validation of a latent construct for dementia case-finding in Mexican-Americans.

Validation of a latent construct for dementia case-finding in Mexican-Americans.
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验证墨西哥裔美国人痴呆症病例发现的潜在结构。

DOI:
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发表时间:
2013
期刊:
Journal of Alzheimer's Disease
影响因子:
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通讯作者:
R. Palmer
R. Palmer
中科院分区:
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文献类型:
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作者:
D. Royall;R. Palmer

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我们构建了一个潜在的痴呆代理“δ”,并在多个数据集中对其进行了验证,其中包括参与德克萨斯州阿尔茨海默病研究和护理联盟 (TARCC) 研究的特征明确的受试者。几乎可以从认知和功能状态测量的任何临时组合构建 δ 同系物。 δ 同系物也可能相对不受测量误差的影响,包括文化、语言或教育偏差。这些特性使得从潜在变量得出的因子评分成为农村或少数群体痴呆症病例发现的潜在有吸引力的解决方案。在这里,我们探索了一种替代且更简短的评估,通过它构建 δ 同系物并验证墨西哥裔美国人 (MA) TARCC 受试者中产生的潜在变量 (dMA)。 dMA 由简单的“床边”痴呆症筛查仪器组成,其接收者手术曲线下面积可与 δ 本身相媲美。种族对 dMA 的表现影响很小。这些结果表明,可能可以有效地将 dMA 导出到其他 MA 群体中,或者将 δ 同源因子得分从一个群体导出到另一个群体。
We have constructed a latent dementia proxy, "δ", and validated it in several datasets, including well characterized subjects participating in the Texas Alzheimer's Research and Care Consortium (TARCC) study. It may be possible to construct δ homologs from almost any ad hoc combination of cognitive and functional status measures. δ homologs may also be relatively immune to measurement error, including cultural, linguistic, or educational biases. These properties make factor scores derived from latent variables a potentially attractive solution for dementia case-finding in rural or minority populations. Here we have explored an alternative and briefer assessment by which to construct a δ homolog and validate the resulting latent variable (dMA) in Mexican-American (MA) TARCC subjects. dMA, composed of simple "bedside" dementia screening instruments, achieves Areas Under the Receiver Operative Curve that rival those of δ itself. Ethnicity has a small effect on dMA's performance. These results suggest that it may be possible to validly export dMA into other MA populations, or to export δ homolog factor scores from one population to another.
DOI: 10.1001/archneur.65.8.1091
发表时间: 2008-08
影响因子: --
作者:
O'Bryant, Sid E.;Waring, Stephen C.;Cullum, C. Munro;Hall, James;Lacritz, Laura;Massman, Paul J.;Lupo, Philip J.;Reisch, Joan S.;Doody, Rachelle
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DOI: --
发表时间: 2004
期刊: Ethnicity & disease.
影响因子: --
作者:
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通讯作者: Markides,KyriakosS