Staging dementia using Clinical Dementia Rating Scale Sum of Boxes scores: a Texas Alzheimer's research consortium study.
Staging dementia using Clinical Dementia Rating Scale Sum of Boxes scores: a Texas Alzheimer's research consortium study.
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DOI：
10.1001/archneur.65.8.1091
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发表时间：
2008-08
影响因子：
--
通讯作者：
Doody, Rachelle
中科院分区：
文献类型：
--
作者：
O'Bryant, Sid E.;Waring, Stephen C.;Cullum, C. Munro;Hall, James;Lacritz, Laura;Massman, Paul J.;Lupo, Philip J.;Reisch, Joan S.;Doody, Rachelle
临床痴呆症评定量表总和(CDR-SOB)评分是常用的，尽管关于这一评分在痴呆严重程度分期中的效用尚未得到很好的确立。目的：探讨CDRSOB评分与全球CDR评分在痴呆严重程度分期中的有效性。回溯性研究。德克萨斯州阿尔茨海默氏症研究联盟最低数据集队列。共有1577名参与者(110名对照组，202名轻度认知障碍患者，1265名可能患有阿尔茨海默病的患者)可用于分析。从派生样本生成接收器工作特性曲线，以确定最佳截止分数和范围，然后将其应用于验证样本。与全球CDR分数相对应的CDR-SOB分数的最佳范围是：全球分数为0.5至4.0，全球分数为1.0为4.5至9.0，全球分数为2.0为9.5至15.5，全球分数为3.0为16.0至18.0。当应用于验证样本时，κ分数从0.86到0.94(P<；所有人都是.001)，93.0%的参与者属于新的分期类别。CDR-SOB评分与全球痴呆症分期的CDR评分相当。由于数值范围的扩大，CDR-SOB评分比全球评分提供了几个优势，包括在跟踪痴呆症严重程度阶段内和阶段之间的变化方面增加了实用性。提供了CDR-SOB评分的解释性指南。
The Clinical Dementia Rating Scale Sum of Boxes (CDR-SOB) score is commonly used, although the utility regarding this score in staging dementia severity is not well established. To investigate the effectiveness of CDRSOB scores in staging dementia severity compared with the global CDR score. Retrospective study. Texas Alzheimer's Research Consortium minimum data set cohort. A total of 1577 participants (110 controls, 202 patients with mild cognitive impairment, and 1265 patients with probable Alzheimer disease) were available for analysis. Receiver operating characteristic curves were generated from a derivation sample to determine optimal cutoff scores and ranges, which were then applied to the validation sample. Optimal ranges of CDR-SOB scores corresponding to the global CDR scores were 0.5 to 4.0 for a global score of 0.5, 4.5 to 9.0 for a global score of 1.O, 9.5 to 15.5 for a global score of 2.0, and 16.0 to 18.0 for a global score of 3.0. When applied to the validation sample, κ scores ranged from 0.86 to 0.94 (P <.001 for all), with 93.0% of the participants falling within the new staging categories. The CDR-SOB score compares well with the global CDR score for dementia staging. Owing to the increased range of values, the CDR-SOB score offers several advantages over the global score, including increased utility in tracking changes within and between stages of dementia severity. Interpretive guidelines for CDR-SOB scores are provided.
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影响因子：
9.9
作者：
Morris, JC;Storandt, M;Berg, L
通讯作者：
Berg, L
影响因子：
--
作者：
Grundman, M;Petersen, RC;Thal, LJ
通讯作者：
Thal, LJ
影响因子：
9.9
作者：
MCKHANN, G;DRACHMAN, D;STADLAN, EM
通讯作者：
STADLAN, EM
影响因子：
5.4
作者：
Andersen, K;Lolk, A;Green, A
通讯作者：
Green, A
影响因子：
9.9
作者：
Morris, JC;Ernesto, C;Thal, LJ
通讯作者：
Thal, LJ