Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers.
Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers.
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DOI：
10.1038/sj.bjc.6603012
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发表时间：
2006-03-13
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
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比较患有子宫乳头状浆液性癌 (UPSC) 和透明细胞癌 (CC) 的女性与患有 3 级子宫内膜样子宫癌 (G3EC) 的女性的生存率。从 1988 年至 2001 年的监测、流行病学和最终结果计划中获得人口统计、病理、治疗和生存信息。使用 Kaplan-Meier 和 Cox 比例风险回归方法对数据进行分析。在 4180 名女性中，1473 名患有 UPSC，391 名患有 CC，2316 名患有 G3EC 癌症。与 G3EC 相比，子宫乳头状浆液性癌和 CC 患者年龄较大（中位年龄分别为 70 岁和 68 岁 vs 66 岁；P<0.0001），并且更有可能是黑人（15% 和 12% vs 7%；P<0.0001）。与 G3EC 患者相比，UPSC 和 CC 患者患有 III-IV 期疾病的比例较高（52% 和 36% vs 29%；P<0.0001）。子宫乳头状浆液性癌、CC 和 G3EC 患者分别占子宫内膜癌的 10%、3% 和 15%，但分别占癌症死亡的 39%、8% 和 27%。患有 UPSC、CC 和 G3EC 的女性的 5 年疾病特异性生存率分别为 55%、68% 和 77%（P<0.0001）。在控制 I-II 期（74%、82% 和 86%；P<0.0001）和 III-IV 期疾病（33%、40% 和 54%；P<0.0001）后，UPSC、CC 和 G3EC 之间的生存率差异仍然存在。在多变量分析中，更有利的组织学（G3EC）、更年轻的年龄和更早的分期是改善生存的独立预测因素。与患有 G3EC 的女性相比，患有 UPSC 和子宫 CC 的女性预后明显较差。在对这些高危患者进行咨询、治疗和设计未来试验时应考虑这些发现。
To compare the survival of women with uterine papillary serous carcinoma (UPSC) and clear cell carcinoma (CC) to those with grade 3 endometrioid uterine carcinoma (G3EC). Demographic, pathologic, treatment, and survival information were obtained from the Surveillance, Epidemiology, and End Results Program from 1988 to 2001. Data were analysed using Kaplan–Meier and Cox proportional hazards regression methods. Of 4180 women, 1473 had UPSC, 391 had CC, and 2316 had G3EC cancers. Uterine papillary serous carcinoma and CC patients were older (median age: 70 years and 68 vs 66 years, respectively; P<0.0001) and more likely to be black compared to G3EC (15 and 12% vs 7%; P<0.0001). A higher proportion of UPSC and CC patients had stage III–IV disease compared to G3EC patients (52 and 36% vs 29%; P<0.0001). Uterine papillary serous carcinoma, CC and G3EC patients represent 10, 3, and 15% of endometrial cancers but account for 39, 8, and 27% of cancer deaths, respectively. The 5-year disease-specific survivals for women with UPSC, CC and G3EC were 55, 68, and 77%, respectively (P<0.0001). The survival differences between UPSC, CC and G3EC persist after controlling for stage I–II (74, 82, and 86%; P<0.0001) and stage III–IV disease (33, 40, and 54; P<0.0001). On multivariate analysis, more favourable histology (G3EC), younger age, and earlier stage were independent predictors of improved survival. Women with UPSC and CC of the uterus have a significantly poorer prognosis compared to those with G3EC. These findings should be considered in the counselling, treating and designing of future trials for these high-risk patients.
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影响因子：
4.7
作者：
Cirisano, FD;Robboy, SJ;Clarke-Pearson, DL
通讯作者：
Clarke-Pearson, DL
影响因子：
5.6
作者：
HENDRICKSON, M;ROSS, J;KEMPSON, R
通讯作者：
KEMPSON, R
DOI：
10.1016/0002-9378(91)90628-5
发表时间：
1991-01-01
影响因子：
9.8
作者：
TYLER, CW;LEE, NC;WILLIAMSON, GD
通讯作者：
WILLIAMSON, GD
DOI：
10.1016/s0360-3016(02)02913-9
发表时间：
2002-09-01
影响因子：
7
作者：
Alektiar, KM;McKee, A;Barakat, RR
通讯作者：
Barakat, RR
影响因子：
6.2
作者：
Boruta, DM;Gehrig, PA;Van Le, L
通讯作者：
Van Le, L