Continuous ambulatory peritoneal dialysis and bone.
Continuous ambulatory peritoneal dialysis and bone.
复制标题
持续门诊腹膜透析和骨透析。
作者：
J. Delmez;M. Fallon;M. Bergfeld;B. Gearing;C. Dougan;S. Teitelbaum
我们研究了持续非卧床腹膜透析（CAPD）对尿毒症性骨病组织学表现的影响。12名患者在治疗前和治疗后一年立即进行骨活检。那些具有大量非矿化骨基质（类骨质）的患者经历了相对类骨质体积、平均类骨质接缝宽度和总类骨质表面的减少。此外，使用矿化的时间间隔动力学标记物（四环素）使我们能够证明CAPD通常通过缩短矿化滞后时间（即，从有机基质沉积到其矿化的时间间隔）来减少非矿化骨基质的量。组织形态学的变化似乎与骨铝无关。这些数据表明，CAPD通常提高了个体成骨细胞的矿化能力，并表明这种治疗对尿毒症骨骼有益。
We studied the effects of continuous ambulatory peritoneal dialysis (CAPD) on the histological manifestations of uremic bone disease. Twelve patients underwent bone biopsy immediately prior to and after one year of such treatment. Those with larger quantities of non-mineralized bone matrix (osteoid) experienced a reduction in relative osteoid volume, mean osteoid seam width, and total osteoid surface. Moreover, the use of time-spaced kinetic markers of mineralization (tetracycline) enabled us to demonstrate that CAPD usually decreased the amount of non-mineralized bone matrix by shortening mineralization lag time (that is, the interval from organic matrix deposition to its mineralization). The changes in the histomorphology appeared to occur independently of bone aluminum. These data indicate that CAPD generally enhances the mineralizing capacity of individual osteoblasts and suggests that such therapy is beneficial to the uremic skeleton.
连续不卧床腹膜透析中的矿物质、维生素 D 和甲状旁腺激素。
影响因子：
19.6
作者：
Delmez,JA;Slatopolsky,E;Martin,KJ;Gearing,BN;Harter,HR
通讯作者：
Harter,HR
肾衰竭患者髂骨中铝的组织学定量。
DOI：
--
发表时间：
1982
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Maloney,NA;Ott,SM;Alfrey,AC;Miller,NL;Coburn,JW;Sherrard,DJ
通讯作者：
Sherrard,DJ