Plasma Membrane Integrates Biophysical and Biochemical Regulation to Trigger Immune Receptor Functions.
Plasma Membrane Integrates Biophysical and Biochemical Regulation to Trigger Immune Receptor Functions.
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DOI：
10.3389/fimmu.2021.613185
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发表时间：
2021
影响因子：
7.3
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Zhang T;Hu W;Chen W
质膜为免疫细胞提供了生物物理和生物化学平台，以触发信号级联和免疫应答，以抵抗外来病原体或肿瘤细胞的攻击。越来越多的证据表明，该平台的生物药理学-化学性质，包括脂质和胆固醇的复杂组合物、膜张力和电位，可以协同调节免疫受体功能。然而，由于质膜成分的复杂性和时空动态性，其分子机制尚不清楚。本文综述了近年来质膜对免疫受体（包括T细胞受体、B细胞受体、Fc受体等重要免疫受体）的动态调节，以实现机械化学传感和跨膜信号转导的重要研究进展。我们还讨论了生物药理学-化学线索如何耦合在一起，以动态调整受体的结构构象或方向，分布和组织，从而可能影响其原位配体结合和相关的信号转导。此外，我们提出，电位可能会引起生物-化学耦合的变化，如脂质分布和膜张力，不可避免地调节免疫受体的激活。
Plasma membrane provides a biophysical and biochemical platform for immune cells to trigger signaling cascades and immune responses against attacks from foreign pathogens or tumor cells. Mounting evidence suggests that the biophysical-chemical properties of this platform, including complex compositions of lipids and cholesterols, membrane tension, and electrical potential, could cooperatively regulate the immune receptor functions. However, the molecular mechanism is still unclear because of the tremendous compositional complexity and spatio-temporal dynamics of the plasma membrane. Here, we review the recent significant progress of dynamical regulation of plasma membrane on immune receptors, including T cell receptor, B cell receptor, Fc receptor, and other important immune receptors, to proceed mechano-chemical sensing and transmembrane signal transduction. We also discuss how biophysical-chemical cues couple together to dynamically tune the receptor’s structural conformation or orientation, distribution, and organization, thereby possibly impacting their in-situ ligand binding and related signal transduction. Moreover, we propose that electrical potential could potentially induce the biophysical-chemical coupling change, such as lipid distribution and membrane tension, to inevitably regulate immune receptor activation.
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影响因子：
5.5
作者：
Bernardino de la Serna J;Schütz GJ;Eggeling C;Cebecauer M
通讯作者：
Cebecauer M
影响因子：
4.6
作者：
Baier, Carlos J.;Fantini, Jacques;Barrantes, Francisco J.
通讯作者：
Barrantes, Francisco J.
影响因子：
4.4
作者：
Brezski, Randall J.;Monroe, John G.
通讯作者：
Monroe, John G.
霍乱毒素B通过促进脂质筏聚集来加速狼疮易发的疾病进展。
DOI：
10.4049/jimmunol.181.6.4019
发表时间：
2008-09-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Deng GM;Tsokos GC
通讯作者：
Tsokos GC
影响因子：
4.1
作者：
Fernandes, MJG;Rollet-Labelle, E;Naccache, PH
通讯作者：
Naccache, PH