There Is No Simple Model of the Plasma Membrane Organization.
There Is No Simple Model of the Plasma Membrane Organization.
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DOI：
10.3389/fcell.2016.00106
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发表时间：
2016
影响因子：
5.5
通讯作者：
Cebecauer M
中科院分区：
文献类型：
--
作者：
Bernardino de la Serna J;Schütz GJ;Eggeling C;Cebecauer M
自从技术使真核细胞质膜得以表征以来，人们就观察到了其成分分布的不均一性。多年来，这导致了描述质膜组织的各种模型的提出，如脂壳、桩和栅栏、脂筏或蛋白质岛，如在许多出版物和综述中所述。在这篇综述中，我们不是强调一个模型，而是简要概述现有的模型，并强调当前的实验工作如何以这样或那样的方式不支持单一总体模型的存在。取而代之的是，我们重点介绍了膜的各种性质和成分，它们的影响和影响。我们相信，突出这些有争议的发现将刺激对质膜组织和功能的公正研究，从而更好地理解这一重要的细胞结构。
Ever since technologies enabled the characterization of eukaryotic plasma membranes, heterogeneities in the distributions of its constituents were observed. Over the years this led to the proposal of various models describing the plasma membrane organization such as lipid shells, picket-and-fences, lipid rafts, or protein islands, as addressed in numerous publications and reviews. Instead of emphasizing on one model we in this review give a brief overview over current models and highlight how current experimental work in one or the other way do not support the existence of a single overarching model. Instead, we highlight the vast variety of membrane properties and components, their influences and impacts. We believe that highlighting such controversial discoveries will stimulate unbiased research on plasma membrane organization and functionality, leading to a better understanding of this essential cellular structure.
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影响因子：
2.4
作者：
Bozic, B;Kralj-Iglic, V;Svetina, S
通讯作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.0702970105
发表时间：
2008-01-08
影响因子：
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作者：
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