IL-17 and anti-bacterial immunity: protection versus tissue damage.

IL-17 and anti-bacterial immunity: protection versus tissue damage.
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DOI:
10.1002/eji.200839090
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发表时间:
2009-03
影响因子:
5.4
通讯作者:
Cooper, Andrea M.
Cooper, Andrea M.
中科院分区:
医学3区
文献类型:
--
作者:
Cooper, Andrea M.

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IL-17可以通过多种方式影响健康。它对某些病原体有保护作用,但也与组织损伤性炎症有关。通过研究IL-17在各种细菌感染中的作用,可以剖析这种细胞因子介导保护和损伤的机制。理解这种细胞因子作用的一个关键因素是确定它在何时何地起作用。从其免疫病理学作用中剖析其基本保护作用将允许改善对急性和慢性疾病的干预。
IL‐17 can impact health in a variety of ways. It is protective for some pathogens but it is also associated with tissue damaging inflammation. By examining the role of IL‐17 in a variety of bacterial infections the mechanisms by which this cytokine mediates both protection and damage can be dissected. A key element in understanding the role of this cytokine is determining where and when it is acting. Dissecting its essential protective role from its immunopathologic role will allow for improved intervention in both acute and chronic disease.
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