Dynamics of Mechanically Coupled Hair-Cell Bundles of the Inner Ear.
Dynamics of Mechanically Coupled Hair-Cell Bundles of the Inner Ear.
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DOI：
10.1016/j.bpj.2020.11.2273
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发表时间：
2021-01-19
影响因子：
3.4
通讯作者：
Bozovic D
中科院分区：
文献类型：
--
作者：
Roongthumskul Y;Faber J;Bozovic D
由听觉系统执行的声音检测的高灵敏度和有效频率辨别依赖于毛细胞系统的动力学。在内耳中，这些声感受器主要附着在一个覆盖结构上，该结构提供了发束之间的机械耦合。虽然个别发束的动力学已被广泛研究，机械耦合的束系统的运动性的影响仍然不确定。我们开发了一种技术，机械耦合两个活跃的头发束，使我们能够探测耦合系统的动力学实验。我们证明，耦合可以增强毛束的自发振荡的相干性，以及它们对正弦刺激的锁相响应，在接近生理水平的周围流体中的钙浓度。的经验数据是一致的数值结果从两个耦合的非等距振荡器的模型，每个显示超临界Hopf分岔。该模型表明，弱耦合可以平衡系统的不稳定振荡器更接近分叉的临界点的移动。此外，远离临界的强耦合振子的动力学表明，单个发束可以被视为非等轴振子。在耦合系统自主运动的相干性中，所观察到的调谐行为需要一个最佳的非等时性程度。
The high sensitivity and effective frequency discrimination of sound detection performed by the auditory system rely on the dynamics of a system of hair cells. In the inner ear, these acoustic receptors are primarily attached to an overlying structure that provides mechanical coupling between the hair bundles. Although the dynamics of individual hair bundles has been extensively investigated, the influence of mechanical coupling on the motility of the system of bundles remains underdetermined. We developed a technique of mechanically coupling two active hair bundles, enabling us to probe the dynamics of the coupled system experimentally. We demonstrated that the coupling could enhance the coherence of hair bundles’ spontaneous oscillation, as well as their phase-locked response to sinusoidal stimuli, at the calcium concentration in the surrounding fluid near the physiological level. The empirical data were consistent with numerical results from a model of two coupled nonisochronous oscillators, each displaying a supercritical Hopf bifurcation. The model revealed that a weak coupling can poise the system of unstable oscillators closer to the bifurcation by a shift in the critical point. In addition, the dynamics of strongly coupled oscillators far from criticality suggested that individual hair bundles may be regarded as nonisochronous oscillators. An optimal degree of nonisochronicity was required for the observed tuning behavior in the coherence of autonomous motion of the coupled system.
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DOI：
10.1073/pnas.90.4.1330
发表时间：
1993-02-15
影响因子：
11.1
作者：
JARAMILLO, F;HUDSPETH, AJ
通讯作者：
HUDSPETH, AJ
影响因子：
16.2
作者：
Fisher, Jonathan A. N.;Nin, Fumiaki;Hudspeth, A. J.
通讯作者：
Hudspeth, A. J.
DOI：
10.1073/pnas.0913657107
发表时间：
2010-05-04
影响因子：
11.1
作者：
Barral, Jeremie;Dierkes, Kai;Martin, Pascal
通讯作者：
Martin, Pascal
影响因子：
4
作者：
ARONSON, DG;ERMENTROUT, GB;KOPELL, N
通讯作者：
KOPELL, N
影响因子：
16.2
作者：
Dallos, Peter;Wu, Xudong;Zuo, Jian
通讯作者：
Zuo, Jian