Controlled protein delivery in the generation of microvascular networks.
Controlled protein delivery in the generation of microvascular networks.
复制标题
微血管网络的产生中受控蛋白质的传递。
DOI：
10.1007/s13346-012-0122-y
复制
发表时间：
2015-04
影响因子：
5.4
通讯作者：
Saltzman, W. Mark
中科院分区：
文献类型：
--
作者：
Andrejecsk, Jillian W.;Chang, William G.;Pober, Jordan S.;Saltzman, W. Mark
关键词：
新的微血管网络的快速诱导和稳定对于工程化组织的正常功能是必不可少的。为了达到这一目标，许多努力都使用了促血管生成蛋白质（如血管内皮生长因子）来诱导新微血管的形成。这些蛋白质已被证明有希望改善血管形成，但同样清楚的是，这些信号的空间和时间呈现对于实现适当的血管功能是重要的。以局部和持续的方式呈递蛋白质的递送系统可以通过在所需位置精确呈递促血管生成蛋白质并持续特定的持续时间来促进微血管网络的形成和稳定。此外，这些系统允许对多种蛋白质的释放顺序进行一些控制，并且已经清楚的是，这种协调对于全功能和成熟的血管结构的发育至关重要。本文综述了促血管生成蛋白的作用和控释技术的创新，这些技术可以精确地释放这些蛋白，以刺激微血管网络的形成和稳定。
Rapid induction and stabilization of new microvascular networks is essential for the proper functioning of engineered tissues. Many efforts to achieve this goal have used proangiogenic proteins—such as vascular endothelial growth factors—to induce the formation of new microvessels. These proteins have demonstrated promise in improving vascularization, but it is also clear that the spatial and temporal presentation of these signals is important for achieving proper vascular function. Delivery systems that present proteins in a localized and sustained manner, can promote the formation and stabilization of microvascular networks by precisely presenting proangiogenic proteins at desired locations, and for specified durations. Further, these systems allow for some control over the sequence of release of multiple proteins, and it has become clear that such coordination is critical for the development of fully functional and mature vascular structures. This review focuses on the actions of proangiogenic proteins and the innovations in controlled release technologies that precisely deliver these to stimulate microvascular network formation and stabilization.
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影响因子：
6
作者：
Chambers, RC;Leoni, P;Heller, RA
通讯作者：
Heller, RA
影响因子：
4.8
作者：
BAR, RS;BOES, M;HART, MN
通讯作者：
HART, MN
影响因子：
2.8
作者：
Bhang, Suk Ho;Lee, Tae-Jin;Kim, Byung-Soo
通讯作者：
Kim, Byung-Soo
DOI：
10.1073/pnas.0408357102
发表时间：
2005-01-11
影响因子：
11.1
作者：
Enis, DR;Shepherd, BR;Schechner, JS
通讯作者：
Schechner, JS
影响因子：
--
作者：
Elbjeirami, WM;West, JL
通讯作者：
West, JL