Prognostic Evaluation of Preoperative Thermochemoradiotherapy for N3 Cervical Lymph Node Metastases of Oral Cancer
Prognostic Evaluation of Preoperative Thermochemoradiotherapy for N3 Cervical Lymph Node Metastases of Oral Cancer
复制标题
术前热放化疗治疗口腔癌N3颈部淋巴结转移的预后评估
作者：
I. Tohnai;Y. Hayashi;K. Mitsudo;T. Shigetomi;M. Ueda;T. Ishigaki
目的：本研究的目的是评价口腔癌N3颈淋巴结转移的临床疗效、组织病理学疗效以及术前热放化疗的反应。方法：对8例口腔癌合并N3颈淋巴结转移患者进行术前热放化疗。这些患者在手术前接受每周四次的热疗，结合放疗（40 Gy）以及顺铂化疗（CDDP；100 mg/m2）。术前热放化疗完成后4周进行根治性颈清扫术。结果：颈淋巴结转移患者术前治疗部分缓解6例，无变化2例。术后组织病理学按照Shimosato标准，Ⅲ级1例，Ⅱb级4例，Ⅱa级3例。随访期为 13 至 64 个月（平均 34 个月）。 8例患者中，2例死亡（1例淋巴结转移，1例远处转移），末次随访时存活6例，最长术后无病生存63个月。 5年累积生存率为70.0%。结论：这些结果表明，术前热放化疗对于口腔癌 N3 颈淋巴结转移患者来说是一种有前景的治疗方法。
Objective: The purpose of this study was to evaluate the clinical efficacy, histopathological efficacy, and response to preoperative thermochemoradiotherapy for N3 cervical lymph node metastases of oral cancer. Methods: Preoperative thermochemoradiotherapy was performed in 8 patients with oral cancer and N3 cervical lymph node metastasis. These patients underwent four-weekly sessions of hyperthermia, combined with radiotherapy (40 Gy) as well as chemotherapy with cisplatin (CDDP; 100 mg/m2), all prior to surgery. Radical neck dissection was performed 4 weeks after completion of preoperative thermochemoradiotherapy. Results: The preoperative treatment of cervical lymph node metastases yielded a partial response in 6 patients, while 2 patients demonstrated no change. Histopathologically, grade III was detected in 1, grade IIb in 4 and grade IIa in 3 patients after surgery, according to the criteria of Shimosato. The follow-up period ranged from 13 to 64 months (mean 34). Of the 8 patients, 2 died (1 of lymph node metastasis and 1 had metastasis to a distant site), and 6 patients were alive at the last follow-up, with the longest postoperative disease-free survival being 63 months. The 5-year cumulative survival rate was 70.0%. Conclusion: These results indicate that preoperative thermochemoradiotherapy is a promising modality for patients with N3 cervical lymph node metastasis of oral cancer.
放射治疗和热疗联合治疗的 N3 (TNM-UICC) 颈部转移淋巴结：临床结果和治疗参数分析。
DOI：
10.3109/02656738609012394
发表时间：
1986
期刊：
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
影响因子：
--
作者：
Valdagni,R;Kapp,DS;Valdagni,C
通讯作者：
Valdagni,C
DOI：
10.1016/0360-3016(84)90379-1
发表时间：
1984-01-01
影响因子：
7
作者：
SAPARETO, SA;DEWEY, WC
通讯作者：
DEWEY, WC