Long noncoding RNA (lncRNA): a target in neuropathic pain.
Long noncoding RNA (lncRNA): a target in neuropathic pain.
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DOI：
10.1080/14728222.2019.1550075
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发表时间：
2019-01
影响因子：
5.8
通讯作者：
Tao YX
中科院分区：
文献类型：
--
作者：
Wu S;Bono J;Tao YX
Current treatments for neuropathic pain are limited at least in part due to the incomplete understanding of its underlying mechanisms. Recent evidence reveals the dysregulated expression of long non-coding RNAs (lncRNAs) in the damaged nerve, dorsal root ganglion (DRG), and spinal cord dorsal horn following peripheral nerve injury. However, the role of the majority of lncRNAs in neuropathic pain genesis is still elusive. Unveiling the mechanisms of how lncRNAs participate in neuropathic pain may develop new strategies to prevent and/or treat this disorder. This review focuses on the dysregulation of lncRNAs in the DRG, spinal cord dorsal horn, and the injured peripheral nerves from preclinical rodent models of neuropathic pain. We provide evidence of how peripheral nerve injury causes the dysregulation of lncRNAs in these pain-related regions. The potential mechanisms of how dysregulated lncRNAs contribute to the pathogenesis of neuropathic pain are discussed. The investigation on the role of the dysregulated lncRNAs in neuropathic pain might open up a novel avenue for therapeutic treatment of this disorder. However, current investigation is at the infancy stage, which challenges the translation of preclinical findings. More intensive study on lncRNAs is required before the preclinical findings are translated into therapeutic management for neuropathic pain.
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