Coherence potentials: loss-less, all-or-none network events in the cortex.
Coherence potentials: loss-less, all-or-none network events in the cortex.
复制标题
DOI：
10.1371/journal.pbio.1000278
复制
发表时间：
2010-01-12
期刊：
影响因子：
9.8
通讯作者：
Plenz D
中科院分区：
文献类型：
--
作者：
Thiagarajan TC;Lebedev MA;Nicolelis MA;Plenz D
神经元之间的短暂联系被认为是记忆和行为的基础。然而，人们对这种关联是如何发生的或如何识别它们知之甚少。在这里，我们记录了正在进行的局部场电位（LFP）活动在多个网站内清醒的猴子和皮层器官型文化的皮质。我们发现，当一个本地神经元组的复合活动超过阈值，其活动模式，反映在LFP，发生在其他皮质网站通过快速突触传递没有失真。这些大振幅的LFP，我们称之为相干电位，可以延伸到数百毫秒，并标记时间和振幅信息的无损传播周期，就像单细胞水平的动作电位一样。然而，相干势在其波形的多样性方面具有额外的自由度，这提供了用于编码信息的高维参数，并允许识别特定的关联。这种非线性行为类似于社交网络中思想和行为的传播。感知和行为被认为是由大脑中神经细胞亚群之间的短暂联系产生的。然而，确定在任何给定时间内，许多活跃神经元中的哪些是相关的以及如何相关是一个挑战。在这里，我们表明，当一个本地组的皮层神经元的复合活动，作为一个复杂的波形在胞外场测量，超过一个阈值，其活动模式延伸到数百毫秒发生在其他皮层网站通过快速突触传递没有失真。我们称这些全或无传播模式为“相干电位”，类似于单细胞水平的动作电位。与动作电位不同，动作电位是典型的，因此只能进行二进制编码，相干电位是多样化和复杂的波形，可以作为编码信息的高维参数。地方活动与其复制传播程度之间的非线性关系表明存在一个“引爆点”，类似于社交网络中创新和经济行为的传播，一旦它们在地方聚集到临界质量，就可以迅速传播。
Transient associations among neurons are thought to underlie memory and behavior. However, little is known about how such associations occur or how they can be identified. Here we recorded ongoing local field potential (LFP) activity at multiple sites within the cortex of awake monkeys and organotypic cultures of cortex. We show that when the composite activity of a local neuronal group exceeds a threshold, its activity pattern, as reflected in the LFP, occurs without distortion at other cortex sites via fast synaptic transmission. These large-amplitude LFPs, which we call coherence potentials, extend up to hundreds of milliseconds and mark periods of loss-less spread of temporal and amplitude information much like action potentials at the single-cell level. However, coherence potentials have an additional degree of freedom in the diversity of their waveforms, which provides a high-dimensional parameter for encoding information and allows identification of particular associations. Such nonlinear behavior is analogous to the spread of ideas and behaviors in social networks. Perception and behavior are thought to arise from transient associations among sub-groups of nerve cells in the brain. However, identifying which of the many active neurons are associated at any given time and how poses a challenge. Here we show that when the composite activity of a local group of cortical neurons, measured as a complex waveform in the extracellular field, exceeds a threshold, its activity pattern extending up to hundreds of milliseconds occurs without distortion at other cortical sites via fast synaptic transmission. We call these all-or-none propagated patterns “coherence potentials”, in analogy to action potentials at the single cell level. In contrast to action potentials, which are stereotypical and thus capable only of binary coding, coherence potentials are diverse and complex waveforms that can serve as a high-dimensional parameter for encoding information. The non-linear relationship between local activity and its extent of replicated spread suggests a “tipping point” that bears analogy to the propagation of innovations and economic behavior in social networks, which can spread rapidly once they have garnered a local critical mass.
登录
查看更多内容
DOI：
10.1073/pnas.0736909100
发表时间：
2003-04-15
影响因子：
11.1
作者：
Buonomano, DV
通讯作者：
Buonomano, DV
影响因子：
2.5
作者：
AERTSEN, AMHJ;GERSTEIN, GL;PALM, G
通讯作者：
PALM, G
影响因子：
16.2
作者：
Ferezou, Isabelle;Haiss, Florent;Petersen, Carl C. H.
通讯作者：
Petersen, Carl C. H.
DOI：
10.1111/j.1467-8306.1971.tb00806.x
发表时间：
1971-01-01
期刊：
ANNALS OF THE ASSOCIATION OF AMERICAN GEOGRAPHERS
影响因子：
--
作者：
BROWN, LA;COX, KR
通讯作者：
COX, KR
影响因子：
5.7
作者：
Friston, KJ
通讯作者：
Friston, KJ