Dysregulated long noncoding RNAs (lncRNAs) in hepatocellular carcinoma: implications for tumorigenesis, disease progression, and liver cancer stem cells.
Dysregulated long noncoding RNAs (lncRNAs) in hepatocellular carcinoma: implications for tumorigenesis, disease progression, and liver cancer stem cells.
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DOI：
10.1186/s12943-017-0734-4
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发表时间：
2017-10-23
期刊：
影响因子：
37.3
通讯作者：
Qiao L
中科院分区：
文献类型：
--
作者：
Huo X;Han S;Wu G;Latchoumanin O;Zhou G;Hebbard L;George J;Qiao L
肝细胞癌（HCC）是世界范围内最常见的恶性肿瘤之一，预后不良。虽然早期肿瘤可以通过肝移植或手术切除等治疗方法进行治疗，但这些方法仅适用于少数患者。晚期患者仅适用于支持性治疗，大多数对常规化疗或放疗有抵抗力。肝癌干细胞（LCSCs）是一小部分具有无限分化能力和肿瘤形成潜力的癌细胞。为了开发新的肝癌治疗方法，我们需要了解癌症是如何发展的，以及为什么会出现治疗耐药性。使用高通量测序技术，已经鉴定出大量失调的长链非编码RNA（lncRNA），其中一些与肝癌病理、进展、结果的关键方面以及维持癌症干细胞样特性密切相关。此外，一些lncRNA是HCC诊断的潜在生物标志物，并可作为治疗靶点。本文综述了最近报道的lncRNA的数据，可能是至关重要的LCSCs的生物学特性的维持。
Hepatocellular carcinoma (HCC) is one of the most common malignant tumours with a poor prognosis worldwide. While early stage tumours can be treated with curative approaches such as liver transplantation or surgical resection, these are only suitable for a minority of patients. Those with advanced stage disease are only suitable for supportive approaches and most are resistant to the conventional chemotherapy or radiotherapy. Liver cancer stem cells (LCSCs) are a small subset of cancer cells with unlimited differentiation ability and tumour forming potential. In order to develop novel therapeutic approaches for HCC, we need to understand how the cancer develops and why treatment resistance occurs. Using high-throughput sequencing techniques, a large number of dysregulated long noncoding RNAs (lncRNAs) have been identified, and some of which are closely linked to key aspects of liver cancer pathology, progression, outcomes and for the maintenance of cancer stem cell-like properties. In addition, some lncRNAs are potential biomarkers for HCC diagnosis and may serve as the therapeutic targets. This review summarizes data recently reported lncRNAs that might be critical for the maintenance of the biological properties of LCSCs.
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