Cholesterol asymmetry in synaptic plasma membranes.
Cholesterol asymmetry in synaptic plasma membranes.
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DOI：
10.1111/j.1471-4159.2010.07017.x
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发表时间：
2011-03
影响因子：
4.7
通讯作者：
Eckert GP
中科院分区：
文献类型：
--
作者：
Wood WG;Igbavboa U;Müller WE;Eckert GP
脂质对于膜的结构和功能完整性是必不可少的。膜脂不是随机分布的，而是定位于不同的结构域。这些膜结构域的共同特征是它们与胆固醇的结合。脂筏和小窝是胆固醇富集结构域的例子，引起了人们的浓厚兴趣。然而，另外两个重要的胆固醇结构域是质膜的外表面和细胞表面小叶。组成双层的两个小叶在流动性、电荷、脂质分布和某些蛋白质的活性位点方面不同。突触质膜（SPM）胞面小叶含有超过85%的总SPM胆固醇相比，外表面小叶。胆固醇的这种不对称分布不是固定的或固定的，而是可以通过体内不同条件进行改变：1）慢性乙醇消耗; 2）他汀类药物; 3）衰老;和4）apoE同种型。已经提出了几个潜在的候选人参与SPM胆固醇不对称性的调节机制：载脂蛋白E，低密度脂蛋白受体，固醇载体蛋白-2，脂肪酸结合蛋白，多不饱和脂肪酸，p-糖蛋白和小窝蛋白-1。本文综述了SPM中的胆固醇不对称性，潜在的调节机制以及对膜结构和功能的影响。
Lipids are essential for the structural and functional integrity of membranes. Membrane lipids are not randomly distributed but are localized in different domains. A common characteristic of these membrane domains is their association with cholesterol. Lipid rafts and caveolae are examples of cholesterol enriched domains, which have attracted keen interest. However, two other important cholesterol domains are the exofacial and cytofacial leaflets of the plasma membrane. The two leaflets that make up the bilayer differ in their fluidity, electrical charge, lipid distribution, and active sites of certain proteins. The synaptic plasma membrane (SPM) cytofacial leaflet contains over 85% of the total SPM cholesterol as compared with the exofacial leaflet. This asymmetric distribution of cholesterol is not fixed or immobile but can be modified by different conditions in vivo: 1) chronic ethanol consumption; 2) statins; 3) aging; and 4) apoE isoform. Several potential candidates have been proposed as mechanisms involved in regulation of SPM cholesterol asymmetry: apoE, low-density-lipoprotein receptor, sterol carrier protein-2, fatty acid binding proteins, polyunsaturated fatty acids, p-glycoprotein and caveolin-1. This review examines cholesterol asymmetry in SPM, potential mechanisms of regulation and impact on membrane structure and function.
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影响因子：
--
作者：
Levitan, Irena;Fang, Yun;Rosenhouse-Dantsker, Avia;Romanenko, Victor
通讯作者：
Romanenko, Victor
影响因子：
3.3
作者：
Igbavboa, U.;Sun, G. Y.;Wood, W. G.
通讯作者：
Wood, W. G.
DOI：
10.1016/0005-2736(88)90460-9
发表时间：
1988-12-08
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
SCHROEDER, F;MORRISON, WJ;WOOD, WG
通讯作者：
WOOD, WG
DOI：
10.1007/978-90-481-8622-8_10
发表时间：
2010-01-01
期刊：
CHOLESTEROL BINDING AND CHOLESTEROL TRANSPORT PROTEINS: STRUCTURE AND FUNCTION IN HEALTH AND DISEASE
影响因子：
--
作者：
Schroeder, Friedhelm;Huang, Huan;Kier, Ann B.
通讯作者：
Kier, Ann B.
DOI：
10.1073/pnas.162366399
发表时间：
2002-08-06
影响因子：
11.1
作者：
Garrigues, A;Escargueil, AE;Orlowski, S
通讯作者：
Orlowski, S