Topical triiodothyronine stimulates epidermal proliferation, dermal thickening, and hair growth in mice and rats.
Topical triiodothyronine stimulates epidermal proliferation, dermal thickening, and hair growth in mice and rats.
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外用三碘甲状腺原氨酸可刺激小鼠和大鼠的表皮增殖、真皮增厚和毛发生长。
作者：
J. Safer;Lisa M. Fraser;S. Ray;M. Holick
皮肤是甲状腺激素作用的典型靶组织。尽管甲状腺功能减退状态下皮肤的组织学已有详细记录，但文献很少对甲状腺毒症状态下的皮肤进行评估。鉴于有关甲状腺激素过多影响下皮肤的信息很少，我们研究了甲状腺激素对皮肤的直接影响。每天将脂质体中的三碘甲状腺原氨酸 (T3) 局部涂抹于 SKH-1 无毛小鼠，持续 7 天，持续 2 周，持续涂抹至 CD 大鼠。 T3 治疗动物的表皮增殖、真皮增厚和毛发生长呈剂量依赖性增加。接受 3.8 微克 T3 的小鼠每毫米毛发数量比对照组多 42% (p < 0.01)，毛发长度长 1,180% (p < 0.001)，表皮 3H-胸苷掺入量增加 49% (p < 0.01)，5-溴-2'-脱氧尿苷 (BrdU) 染色细胞多 80% (p < 0.01)。 < 0.05）。接受 12.8 微克 T3 的大鼠的真皮厚度比对照组增加 48% (p < 0.001)，表皮厚度增加 26% (p < 0.001)，每毫米毛发数量增加 85% (p < 0.005)，表皮中 3H-胸苷掺入量增加 130% (p < 0.01)。因此，局部应用甲状腺激素对皮肤和毛发生长具有显着影响。这些观察结果为开发甲状腺激素及其类似物以治疗皮肤和毛发生长疾病提供了新策略。
The skin is a classic target tissue for thyroid hormone action. Although the histology of skin in hypothyroid states is well documented, the literature contains little assessment of skin in thyrotoxic states. In light of the paucity of information on skin under the influence of excess thyroid hormone, we investigated the direct effect of thyroid hormone on skin. Triiodothyronine (T3) was applied topically daily in liposomes to SKH-1 hairless mice for 7 days and to CD rats for 2 weeks. There was a dose-dependent increase in epidermal proliferation, dermal thickening, and hair growth in T3-treated animals. Mice that received 3.8 microg of T3 had 42% more hairs per millimeter than controls (p < 0.01), hair length that was 1,180% longer (p < 0.001), 49% greater epidermal 3H-thymidine incorporation (p < 0.01), and 80% more 5-bromo-2'-deoxyuridine (BrdU) stained cells (p < 0.05). Rats receiving 12.8 microg T3 had 48% greater dermal thickness than controls (p < 0.001), 26% greater epidermal thickness (p < 0.001), 85% more hairs per millimeter (p < 0.005), and 130% greater 3H-thymidine incorporation into the epidermis (p < 0.01). Thus, topically applied thyroid hormone has dramatic effects on both skin and hair growth. These observations offer a new strategy for developing thyroid hormone and its analogues for treating disorders of skin and hair growth.
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影响因子：
56.9
作者：
Ahmad, W;Haque, WFU;Christiano, AM
通讯作者：
Christiano, AM
影响因子：
4.4
作者：
Ahmad, W;Zlotogorski, A;Christiano, AM
通讯作者：
Christiano, AM
DOI：
10.1073/pnas.91.17.8014
发表时间：
1994-08-16
影响因子：
11.1
作者：
HOLICK, MF;RAY, S;PERSONS, KS
通讯作者：
PERSONS, KS
培养物中的人表皮角质形成细胞通过 II 型碘甲状腺原氨酸脱碘将甲状腺素转化为 3,5,3-三碘甲状腺原氨酸：皮肤的一种新内分泌功能。
DOI：
10.1210/jcem-66-4-815
发表时间：
1988
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Kaplan,MM;Pan,CY;Gordon,PR;Lee,JK;Gilchrest,BA
通讯作者：
Gilchrest,BA