Attentional control activation relates to working memory in attention-deficit/hyperactivity disorder.
Attentional control activation relates to working memory in attention-deficit/hyperactivity disorder.
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DOI：
10.1016/j.biopsych.2009.10.036
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发表时间：
2010-04-01
影响因子：
10.6
通讯作者：
Banich, Marie T.
中科院分区：
文献类型：
--
作者：
Burgess, Gregory C.;Depue, Brendan E.;Ruzic, Luka;Willcutt, Erik G.;Du, Yiping P.;Banich, Marie T.
关键词：
注意力缺陷/多动障碍 (ADHD) 患者的注意力控制困难可能反映了工作记忆 (WM) 能力较差，特别是因为工作记忆能力和注意力控制依赖于相似的大脑区域。目前的研究检验了 WM 能力是否可以解释注意力缺陷多动症成人和正常对照组在注意力需求期间大脑激活的群体差异。参与者是 20 名患有 ADHD 联合亚型且没有共存精神或学习障碍的成年人，以及 23 名年龄、智商和性别相似的对照者。 WM 测量值是从 WAIS-III 和 WMS-R 获得的。在执行 Color-Word Stroop 任务时，通过功能磁共振成像 (fMRI) 评估大脑激活情况。 WM 能力的群体差异解释了左背外侧前额叶皮层 (DLPFC) 的部分激活，这与任务相关信息的注意力集的创建和维护有关。此外，在 ADHD 组中，更强的 WM 能力预示着与刺激驱动的注意力和反应选择过程相关的大脑区域的激活增加，但在对照组中则不然。患有混合型 ADHD 的年轻人无法维持适当的任务集，与左侧 DLPFC 活动减少有关，部分原因可能是 WM 能力差。此外，在患有多动症的个体中，较高的思维管理能力可能与刺激驱动的注意力和反应选择过程的增加有关，也许作为一种补偿策略。
Attentional control difficulties in individuals with attention-deficit/ hyperactivity disorder (ADHD) might reflect poor working memory (WM) ability, especially as WM ability and attentional control rely on similar brain regions. The current study examined whether WM ability might explain group differences in brain activation between adults with ADHD and normal controls during attentional demand. Participants were 20 adults with ADHD combined subtype with no comorbid psychiatric or learning disorders, and 23 controls similar in age, IQ, and gender. WM measures were obtained from the WAIS-III and WMS-R. Brain activation was assessed with functional magnetic resonance imaging (fMRI) while performing a Color-Word Stroop task. Group differences in WM ability explained a portion of the activation in left dorsolateral prefrontal cortex (DLPFC), which has been related to the creation and maintenance of an attentional set for task-relevant information. In addition, greater WM ability predicted increased activation of brain regions related to stimulus-driven attention and response selection processes in the ADHD group, but not in the control group. The inability to maintain an appropriate task set in young adults with combined type ADHD, associated with decreased activity in left DLPFC, may in part be due to poor WM ability. Furthermore, in individuals with ADHD, higher WM ability may relate to increased recruitment of stimulus-driven attention and response selection processes, perhaps as a compensatory strategy.
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DOI：
10.1111/j.1469-7610.2006.01671.x
发表时间：
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影响因子：
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