The effect of butylated hydroxytoluene, with and without cortisol, on stimulated lymphocytes.
The effect of butylated hydroxytoluene, with and without cortisol, on stimulated lymphocytes.
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丁基化羟基甲苯（有或没有皮质醇）对刺激的淋巴细胞的影响。
DOI：
10.1016/0024-3205(92)90207-6
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发表时间：
1992
期刊：
影响因子：
6.1
通讯作者：
B. Bruser
中科院分区：
文献类型：
--
作者：
A. Klein;B. Bruser
在目前的工作中，我们承诺，以确定是否丁基羟基甲苯（BHT），这是在食品中使用的抗氧化剂，能够抑制人类淋巴细胞刺激或协同作用与皮质醇和泼尼松龙达到相同的目的。在高于100 μg/ml的浓度下观察到BHT细胞毒性。在0.0 ~ 60.0 μg/ml浓度范围内，BHT对PHA刺激的淋巴细胞摄取~ 3 H-胸苷无影响。然而，50 μg/mL BHT抑制混合淋巴细胞反应（MLR）。当细胞在皮质醇或泼尼松龙存在下与BHT孵育时，观察到PHA刺激的淋巴细胞抑制的协同效应。
In the present work we undertook to ascertain whether butylated hydroxtoluene (BHT), which is used in food as an antioxidant, is capable of either inhibiting human lymphocyte stimulation or acting synergistically with cortisol and prednisolone to the same end. BHT cytotoxicity was observed at concentrations higher than 100 μg/ml. In the concentration range of 0.0 to 60.0 μg/ml, BHT showed no effect on the uptake of3H-Thymidine by PHA stimulated lymphocytes. However, at 50 μg/mL BHT suppressed mixed lymphocyte reaction (MLR). A synergistic effect with regard to suppression of PHA stimulated lymphocytes was observed when the cells were incubated with BHT in the presence of either cortisol or prednisolone.
DOI：
10.1093/jnci/75.5.963
发表时间：
1985-11
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
David G. Beer;Alvin M. Malkinson
通讯作者：
David G. Beer;Alvin M. Malkinson
丁基羟基甲苯对肿瘤发生的多重调节作用。
影响因子：
2.4
作者：
Malkinson,AM
通讯作者：
Malkinson,AM