Differential expression of genes in milk of dairy cattle during lactation.
Differential expression of genes in milk of dairy cattle during lactation.
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奶牛泌乳期乳汁中基因的差异表达。
DOI：
10.1111/age.12394
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发表时间：
2016-04
期刊：
影响因子：
2.4
通讯作者：
Jiang L
中科院分区：
文献类型：
--
作者：
Yang J;Jiang J;Liu X;Wang H;Guo G;Zhang Q;Jiang L
乳脂球是最具代表性的乳腺组织之一，可用于研究泌乳奶牛泌乳期基因表达。本研究利用RNA-seq技术检测了305天产奶量、乳脂产量和乳蛋白产量极高（H组）和极低（L组）两组奶牛产犊后10天和70天MFG基因的差异表达。在H10和L10、H70和L70、H10和H70、L10和L70之间分别检测到1232、81、429和178个显著差异表达基因（假发现率q < 0.05）。基因本体富集和通路分析表明，这些差异表达基因主要集中在乳腺发育、蛋白质和脂质代谢、信号转导、细胞过程、分化和免疫功能等生物学过程中。在这些差异表达基因中，发现178个（H10 vs.L10）、4个（H70 vs.L70）、68个（H10 vs.H70）和22个（L10 vs.L70）位于先前报道的产奶性状QTL区域内。在此基础上，提出了一些有希望的奶牛产奶性状候选基因。
The milk fat globule (MFG) is one of the most representative of mammary gland tissues and can be utilized to study gene expression of lactating cows during lactation. In this study, RNA‐seq technology was employed to detect differential expression of genes in MFGs at day 10 and day 70 after calving between two groups of cows with extremely high (H group) and low (L group) 305‐day milk yield, milk fat yield and milk protein yield. In total, 1232, 81, 429 and 178 significantly differentially expressed genes (false discovery rate q < 0.05) were detected between H10 and L10, H70 and L70, H10 and H70, and L10 and L70 respectively. Gene Ontology enrichment and pathway analysis revealed that these differentially expressed genes were enriched in biological processes involved in mammary gland development, protein and lipid metabolism process, signal transduction, cellular process, differentiation and immune function. Among these differentially expressed genes, 178 (H10 vs. L10), 4 (H70 vs. L70), 68 (H10 vs. H70) and 22 (L10 vs. L70) were found to be located within previously reported QTL regions for milk production traits. Based on these results, some promising candidate genes for milk production traits in dairy cattle were suggested.
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泌乳中的基因调节网络：使用生物信息学对全球原理的识别。
影响因子：
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作者：
Lemay, Danielle G;Neville, Margaret C;Rudolph, Michael C;Pollard, Katherine S;German, J Bruce
通讯作者：
German, J Bruce
DOI：
10.1073/pnas.79.23.7346
发表时间：
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期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
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作者：
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影响因子：
3.5
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6.5
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4.1
作者：
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