Association of neuromyelitis optica with severe and intractable pain.
Association of neuromyelitis optica with severe and intractable pain.
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DOI：
10.1001/archneurol.2012.768
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发表时间：
2012-11
影响因子：
--
通讯作者：
Naismith, Robert T.
中科院分区：
文献类型：
--
作者：
Qian, Peiqing;Lancia, Samantha;Alvarez, Enrique;Klawiter, Eric C.;Cross, Anne H.;Naismith, Robert T.
对比视神经肌萎缩症（NMO）和多发性硬化症（MS）之间疼痛和治疗结果的差异。回顾性、横断面队列研究。学术MS中心完成NMO学术MS中心队列和MS比较样本队列的确定。目前的疼痛是量化的10点量表和麦吉尔疼痛问卷。除了认知、疲劳、抑郁和生活质量的测试外，还收集了扩展残疾状态量表评分和受累脊髓水平的数量。列表显示止痛药的数量和类型。当前疼痛在NMO受试者（n=29）中比MS受试者（n=66）更常见（86.2% vs 40.9%; P<0.001），并且在10分量表上更严重（5.38 vs 1.85; P <0.001）。在控制残疾和脊髓节段数量后，疼痛仍然更常见（P=.03）。与MS受试者相比，NMO受试者更频繁地使用处方止痛药（75.9% vs 37.8%; P<.001），通常需要1种以上药物（65.5% vs 15.2%; P<.001）。没有服用止痛药的NMO受试者（29例中的22例）将其当前疼痛评定为0/10，而几乎一半服用止痛药的MS受试者目前没有疼痛（0% vs 48%; P= 0.006）。视神经肌萎缩症经常与药物干预不能充分控制的严重疼痛相关。未来的研究应该评估多学科和多模式疼痛管理方法的有效性。
To contrast differences in pain and treatment outcomes between neuromyelitis optica (NMO) and multiple sclerosis (MS). Retrospective, cross-sectional cohort study. Academic MS center. Complete ascertainment of an academic MS center cohort of NMO and an MS comparison sample cohort. Current pain was quantified by a 10-point scale and the McGill Pain Questionnaire. Expanded Disability Status Scale score and number of involved spinal cord levels were collected in addition to testing for cognition, fatigue, depression, and quality of life. Number and types of pain medications were tabulated. Current pain was more common in subjects with NMO (n=29) vs MS (n=66) (86.2% vs 40.9%; P<.001) and more severe on a 10-point scale (5.38 vs 1.85; P <.001). Pain remained more common after controlling for disability and number of spinal cord segments (P=.03). Prescription pain medication was used more frequently in subjects with NMO compared with subjects with MS (75.9% vs 37.8%; P<.001), often requiring more than 1 medication (65.5% vs 15.2%; P<.001). No subject with NMO taking pain medication (22 of 29) rated their current pain as 0 of 10, whereas almost half of those taking pain medication with MS were currently free of pain (0% vs 48%; P=.006). Neuromyelitis optica is frequently associated with severe pain that appears insufficiently controlled by pharmacologic interventions. Future studies should evaluate the efficacy of a multidisciplinary and multimodal approach to pain management.
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影响因子：
2.2
作者：
Misu, Tatsuro;Fujihara, Kazuo;Itoyama, Yasuto
通讯作者：
Itoyama, Yasuto
DOI：
10.1097/jnn.0b013e3181b6be96
发表时间：
2009-12
期刊：
The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses
影响因子：
--
作者：
Newland PK;Naismith RT;Ullione M
通讯作者：
Ullione M
影响因子：
9.9
作者：
Wingerchuk, D. M.;Lennon, V. A.;Weinshenker, B. G.
通讯作者：
Weinshenker, B. G.
影响因子：
3.3
作者：
Solaro, C;Brichetto, G;Mancardi, GL
通讯作者：
Mancardi, GL
影响因子：
11.2
作者：
Polman CH;Reingold SC;Banwell B;Clanet M;Cohen JA;Filippi M;Fujihara K;Havrdova E;Hutchinson M;Kappos L;Lublin FD;Montalban X;O'Connor P;Sandberg-Wollheim M;Thompson AJ;Waubant E;Weinshenker B;Wolinsky JS
通讯作者：
Wolinsky JS