Age- and gender-related normal left ventricular deformation assessed by cardiovascular magnetic resonance feature tracking.
Age- and gender-related normal left ventricular deformation assessed by cardiovascular magnetic resonance feature tracking.
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通过心血管磁共振特征跟踪评估的年龄和性别相关的正常左心室变形。
DOI：
10.1186/s12968-015-0123-3
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发表时间：
2015-03-10
期刊：
影响因子：
--
通讯作者：
Buss SJ
中科院分区：
文献类型：
--
作者：
Andre F;Steen H;Matheis P;Westkott M;Breuninger K;Sander Y;Kammerer R;Galuschky C;Giannitsis E;Korosoglou G;Katus HA;Buss SJ
评价左心室功能是心血管磁共振（CMR）的重要任务之一。LV变形受损是各种心脏疾病（如缺血性心脏病或心肌病）心血管结局的强有力预测因素。本研究旨在为健康志愿者参考人群中CMR特征跟踪成像（FTI）算法得出的心肌变形提供参考值。对150名严格选择的健康志愿者（75名男性/女性）的标准短轴和2-，3-和4-腔室向量心电门控CMR电影SSFP序列进行FTI。在1.5T全身MR扫描仪上，使用标准方案中的FTI测量整体峰值和平均径向、周向和纵向心肌收缩期应变值以及舒张早期应变率。径向的总体收缩峰值为36.3 ± 8.7%，内膜周向为−27.2 ± 4.0%，心肌周向为−21.3 ± 3.3%，内膜纵向为−23.4 ± 3.4%，心肌纵向应变为−21.6 ± 3.2%。径向、环向、环向、纵向、舒张早期应变率的峰值分别为-2.1 ± 0.5s-1、2.1 ± 0.6s-1、1.7 ± 0.5s-1、1.8（1.5-2.2）s-1、1.6（1.4-2.0）s-1。男性表现出更高的径向应变比女性，而周向和纵向应变较低，导致较少的负值。女性受试者的周向和纵向应变率显著较高。径向应变随年龄增长而增加，而舒张功能的径向，周向和纵向应变率测量显示出下降。另外10名受试者在12天内接受了两次CMR检查，其周向平均应变的变异系数为-4.8%，纵向平均应变的变异系数为-4.5%。使用FTI的心肌变形分析是一种新颖的技术，当应用于标准电影CMR图像时具有鲁棒性，可提供可靠、客观的全局LV变形量化。由于应变值和应变率在性别和年龄组之间存在部分差异，因此本研究提供的特定参考值的应用是可行的。
Assessment of left (LV) ventricular function is one of the most important tasks of cardiovascular magnetic resonance (CMR). Impairment of LV deformation is a strong predictor of cardiovascular outcome in various cardiac diseases like ischemic heart disease or cardiomyopathies. The aim of the study was to provide reference values for myocardial deformation derived from the CMR feature tracking imaging (FTI) algorithm in a reference population of healthy volunteers. FTI was applied to standard short axis and 2-, 3- and 4-chamber views of vector-ECG gated CMR cine SSFP sequences of 150 strictly selected healthy volunteers (75 male/female) of three age tertiles (mean age 45.8yrs). Global peak and mean radial, circumferential and longitudinal endo- and myocardial systolic strain values as well as early diastolic strain rates were measured using FTI within a standard protocol on a 1.5T whole body MR scanner. Global peak systolic values were 36.3 ± 8.7% for radial, −27.2 ± 4.0% for endocardial circumferential, −21.3 ± 3.3% for myocardial circumferential, −23.4 ± 3.4% for endocardial longitudinal and −21.6 ± 3.2% for myocardial longitudinal strain. Global peak values were -2.1 ± 0.5s−1 for radial, 2.1 ± 0.6s−1 for circumferential endocardial, 1.7 ± 0.5s−1 for circumferential myocardial, 1.8 (1.5-2.2)s−1 for longitudinal endocardial, 1.6 (1.4-2.0)s−1 for longitudinal myocardial early diastolic strain rates. Men showed a higher radial strain than women whereas the circumferential and longitudinal strains were lower resulting in less negative values. Circumferential and longitudinal strain rates were significantly higher in female subjects. Radial strain increased significantly with age whereas the diastolic function measured by the radial, circumferential and longitudinal strain rates showed a decrease. The coefficients of variation determined in ten further subjects, who underwent two CMR examinations within 12 days, were −4.8% for circumferential and −4.5% for longitudinal endocardial mean strains. Myocardial deformation analysis using FTI is a novel technique and robust when applied to standard cine CMR images providing the possibility of a reliable, objective quantification of global LV deformation. Since strain values and strain rates differed partly between genders as well as between age groups, the application of specific reference values as provided by this study is recommendable.
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DOI：
10.1186/1532-429x-15-46
发表时间：
2013-05-28
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Petersen SE;Matthews PM;Bamberg F;Bluemke DA;Francis JM;Friedrich MG;Leeson P;Nagel E;Plein S;Rademakers FE;Young AA;Garratt S;Peakman T;Sellors J;Collins R;Neubauer S
通讯作者：
Neubauer S
影响因子：
5
作者：
Buss, Sebastian J.;Krautz, Birgit;Steen, Henning
通讯作者：
Steen, Henning
DOI：
10.1186/1532-429x-15-95
发表时间：
2013-10-17
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Onishi T;Saha SK;Ludwig DR;Onishi T;Marek JJ;Cavalcante JL;Schelbert EB;Schwartzman D;Gorcsan J 3rd
通讯作者：
Gorcsan J 3rd
影响因子：
6.4
作者：
Schuster, Andreas;Kutty, Shelby;Nagel, Eike
通讯作者：
Nagel, Eike
影响因子：
24
作者：
Neizel, Mirja;Korosoglou, Grigorios;Steen, Henning
通讯作者：
Steen, Henning