Functional boundaries in the human cerebellum revealed by a multi-domain task battery.

Functional boundaries in the human cerebellum revealed by a multi-domain task battery.
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DOI:
10.1038/s41593-019-0436-x
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发表时间:
2019-08
影响因子:
25
通讯作者:
Diedrichsen J
Diedrichsen J
中科院分区:
医学1区
文献类型:
--
作者:
King M;Hernandez-Castillo CR;Poldrack RA;Ivry RB;Diedrichsen J

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有令人信服的证据表明,人类小脑参与了一系列广泛的运动和认知任务。一个基本的问题集中在小脑是否被组织成不同的功能亚区。为了解决这个问题,我们采用了一个丰富的任务电池,旨在挖掘广泛的认知过程。在四次功能性核磁共振过程中,参与者完成了包括47种独特条件的26项不同任务。利用这个多域任务电池的数据,我们得出了小脑皮层的综合功能包裹,并通过预测一组新任务中的功能边界来评估它。新的分组成功地确定了不同的功能子区域,比来自无任务数据的现有分组提供了重大改进。通常用于总结功能数据的小叶边界与功能细分不一致。新的包裹提供了一个功能图谱,以指导未来的神经影像学研究。
There is compelling evidence that the human cerebellum is engaged in a wide array of motor and cognitive tasks. A fundamental question centers on whether the cerebellum is organized into distinct functional subregions. To address this question, we employed a rich task battery designed to tap into a broad range of cognitive processes. During four functional MRI sessions, participants performed a battery of 26 diverse tasks comprising 47 unique conditions. Using the data from this multi-domain task battery, we derived a comprehensive functional parcellation of the cerebellar cortex and evaluated it by predicting functional boundaries in a novel set of tasks. The new parcellation successfully identified distinct functional subregions, providing significant improvements over existing parcellations derived from task-free data. Lobular boundaries, commonly used to summarize functional data, did not coincide with functional subdivisions. The new parcellation provides a functional atlas to guide future neuroimaging studies.
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