Dietary DHA prevents cognitive impairment and inflammatory gene expression in aged male rats fed a diet enriched with refined carbohydrates.
Dietary DHA prevents cognitive impairment and inflammatory gene expression in aged male rats fed a diet enriched with refined carbohydrates.
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DOI：
10.1016/j.bbi.2021.08.214
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Barrientos RM
中科院分区：
文献类型：
--
作者：
Butler MJ;Deems NP;Muscat S;Butt CM;Belury MA;Barrientos RM
近几十年来，富含精制碳水化合物、饱和脂肪和缺乏纤维的加工食品饮食（PD）的消费有所增加，这可能导致人类慢性疾病发病率增加和体重增加。这些饮食也被证明对啮齿动物、非人类灵长类动物和人类的大脑健康和认知功能产生负面影响，可能是通过神经免疫相关机制产生的。然而，帕金森病影响老年大脑的机制尚不清楚。考虑到老年大脑的基线炎症状态较高，使其更容易受到继发性挑战，这种知识上的差距是至关重要的。在这里，我们发现，摄入富含精制碳水化合物来源的PD 28天会损害老年（24个月）F344 × BN大鼠的海马和杏仁核依赖的记忆功能，而不是年轻（3个月）的大鼠。这些记忆缺陷伴随着衰老大鼠海马和杏仁核中IL-1β、CD11b、MHCⅱ类、CD86、NLRP3和补体成分3等炎症基因的表达增加。重要的是，我们还发现，当同样的PD补充omega-3多不饱和脂肪酸DHA时，老年大鼠的这些记忆缺陷和炎症基因表达变化得到改善，从而首次提供了DHA补充可以保护喂食加工食品的老年大鼠的记忆缺陷和炎症基因表达的证据。最后，我们发现，虽然摄入PD会增加年轻和老年大鼠的体重，但这种影响在老年大鼠中被夸大了。衰老也与下丘脑基因表达的显著改变有关，DHA对体重增加或下丘脑基因表达没有影响。总之，我们的数据提供了关于饮食-大脑相互作用的新见解，表明PD消耗可能通过神经免疫机制损害认知功能，而膳食DHA可以改善这一现象。
The consumption of a processed foods diet (PD) enriched with refined carbohydrates, saturated fats, and lack of fiber has increased in recent decades and likely contributed to increased incidence of chronic disease and weight gain in humans. These diets have also been shown to negatively impact brain health and cognitive function in rodents, non-human primates, and humans, potentially through neuroimmune-related mechanisms. However, mechanisms by which PD impacts the aged brain are unknown. This gap in knowledge is critical, considering the aged brain has a heightened state of baseline inflammation, making it more susceptible to secondary challenges. Here, we showed that consumption of a PD, enriched with refined carbohydrate sources, for 28 days impaired hippocampal- and amygdalar-dependent memory function in aged (24 months), but not young (3 months) F344 × BN rats. These memory deficits were accompanied by increased expression of inflammatory genes, such as IL-1β, CD11b, MHC class II, CD86, NLRP3, and complement component 3, in the hippocampus and amygdala of aged rats. Importantly, we also showed that when the same PD is supplemented with the omega-3 polyunsaturated fatty acid DHA, these memory deficits and inflammatory gene expression changes were ameliorated in aged rats, thus providing the first evidence that DHA supplementation can protect against memory deficits and inflammatory gene expression in aged rats fed a processed foods diet. Lastly, we showed that while PD consumption increased weight gain in both young and aged rats, this effect was exaggerated in aged rats. Aging was also associated with significant alterations in hypothalamic gene expression, with no impact by DHA on weight gain or hypothalamic gene expression. Together, our data provide novel insights regarding diet-brain interactions by showing that PD consumption impairs cognitive function likely through a neuroimmune mechanism and that dietary DHA can ameliorate this phenomenon.
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DOI：
10.1523/jneurosci.2173-12.2012
发表时间：
2012-10-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Barrientos RM;Hein AM;Frank MG;Watkins LR;Maier SF
通讯作者：
Maier SF
影响因子：
15.1
作者：
Barrientos, Ruth M.;Watkins, Linda R.;Rudy, Jerry W.;Maier, Steven F.
通讯作者：
Maier, Steven F.
DOI：
10.3390/antiox9111161
发表时间：
2020-11-21
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Gutiérrez-Miranda B;Gallardo I;Melliou E;Cabero I;Álvarez Y;Magiatis P;Hernández M;Nieto ML
通讯作者：
Nieto ML
影响因子：
6.9
作者：
Hwang, Ling-Ling;Wang, Chien-Hua;Chiou, Lih-Chu
通讯作者：
Chiou, Lih-Chu
影响因子：
4.7
作者：
De Smedt-Peyrusse, Veronique;Sargueil, Francoise;Laye, Sophie
通讯作者：
Laye, Sophie