Usual Interstitial Pneumonia is the Most Common Finding in Surgical Lung Biopsies from Patients with Persistent Interstitial Lung Disease Following Infection with SARS-CoV-2.
Usual Interstitial Pneumonia is the Most Common Finding in Surgical Lung Biopsies from Patients with Persistent Interstitial Lung Disease Following Infection with SARS-CoV-2.
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DOI：
10.1016/j.eclinm.2021.101209
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发表时间：
2021-12
影响因子：
15.1
通讯作者：
Myers JL
中科院分区：
文献类型：
--
作者：
Konopka KE;Perry W;Huang T;Farver CF;Myers JL
急性COVID-19消退后，对持续性间质性肺疾病（ILD）的关注日益增加。目前还没有研究报道手术肺活检（SLB）在这一患者群体中的发现。我们在密歇根医学病理数据库中查询了2020年1月至2021年4月期间来自急性COVID-19恢复后持续性ILD患者的SLB。我们回顾性观察研究的载玻片由两名胸部病理学家独立审查，他们不了解患者的临床资料、影像学表现和既往的病理诊断。18例符合纳入标准。其中9例为常规间质性肺炎（UIP）。其中包括2例合并急性肺损伤（ALI）的患者。5例ALI表现为持续性弥漫性肺泡损伤到组织性肺炎。4例患者有脱屑性间质性肺炎（1例），急性和组织性支气管肺炎（1例），或无诊断异常（2例）。与没有UIP的患者相比，UIP患者往往年龄更大，并且在COVID-19之前已经存在肺部疾病。在UIP患者中，slb前胸部计算机断层扫描改变包括磨玻璃间质增厚或周围网状伴支气管扩张；没有UIP患者只使用磨砂玻璃。无UIP患者最常见的x线表现仅为磨玻璃影。在接受covid -19后ILD评估的患者中，UIP是最常见的病理发现。我们的初步数据表明，描述为间质增厚、外周网状和/或支气管扩张的CT改变可能有助于识别以UIP为主要关注的潜在纤维化性慢性间质性肺炎患者。没有校内或校外资金来源支持这项工作。
There is increasing interest in persistent interstitial lung disease (ILD) following resolution of acute COVID-19. No studies have yet reported findings in surgical lung biopsies (SLB) from this patient population. Our Michigan Medicine pathology database was queried for SLB reviewed between January 2020 and April 2021 from patients with persistent ILD following recovery from acute COVID-19. Slides for our retrospective observational study were independently reviewed by two thoracic pathologists, who were blinded to patient clinical data, radiographic findings, and previous pathologic diagnosis. Eighteen cases met inclusion criteria. Of these, nine had usual interstitial pneumonia (UIP). These included two patients with superimposed acute lung injury (ALI). Five cases showed a spectrum of ALI that ranged from persistent diffuse alveolar damage to organizing pneumonia. Four patients had desquamative interstitial pneumonia (1), acute and organizing bronchopneumonia (1), or no diagnostic abnormality (2). Compared to patients without UIP, those with UIP tended to be older and have pre-existing lung disease prior to COVID-19. In patients with UIP, pre-SLB chest computed tomography changes included groundglass with interstitial thickening or peripheral reticulations with bronchiectasis; no UIP patients had groundglass only. The most common radiographic finding in patients without UIP was groundglass opacities only. UIP was the most common pathologic finding in patients undergoing evaluation for post-COVID-19 ILD. Our preliminary data suggests that CT changes described as interstitial thickening, peripheral reticulations, and/or bronchiectasis may be helpful in identifying patients with underlying fibrotic chronic interstitial pneumonia for which UIP is the chief concern. No intramural or extramural funding sources supported this work.
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影响因子：
17.1
作者：
Bharat A;Querrey M;Markov NS;Kim S;Kurihara C;Garza-Castillon R;Manerikar A;Shilatifard A;Tomic R;Politanska Y;Abdala-Valencia H;Yeldandi AV;Lomasney JW;Misharin AV;Budinger GRS
通讯作者：
Budinger GRS
影响因子：
3.5
作者：
Aesif, Scott W.;Bribriesco, Alejandro C.;Mukhopadhyay, Sanjay
通讯作者：
Mukhopadhyay, Sanjay
影响因子：
5.6
作者：
KATZENSTEIN, ALA;FIORELLI, RF
通讯作者：
FIORELLI, RF
DOI：
10.1007/s00428-020-02934-1
发表时间：
2021-03
期刊：
Virchows Archiv : an international journal of pathology
影响因子：
--
作者：
Barisione E;Grillo F;Ball L;Bianchi R;Grosso M;Morbini P;Pelosi P;Patroniti NA;De Lucia A;Orengo G;Gratarola A;Verda M;Cittadini G;Mastracci L;Fiocca R
通讯作者：
Fiocca R
影响因子：
6.4
作者：
Konopka, Kristine E.;Nguyen, Teresa;Myers, Jeffrey L.
通讯作者：
Myers, Jeffrey L.