Peripheral Mechanisms of Itch.

Peripheral Mechanisms of Itch.
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DOI:
10.1016/j.jid.2021.10.024
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发表时间:
2022-01
影响因子:
6.5
通讯作者:
Liu, Qin
Liu, Qin
中科院分区:
医学1区
文献类型:
--
作者:
Guo, Changxiong J.;Grabinski, Nathaniel S.;Liu, Qin

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瘙痒是一种普遍存在的感觉,慢性瘙痒可能会像疼痛一样使人衰弱。最近的进展不仅确定了神经元瘙痒感应电路,而且还揭示了皮肤和免疫细胞之间复杂的相互作用,这些细胞与神经元一起识别引起瘙痒的刺激物。在这篇综述中,我们将总结皮肤急性瘙痒检测的基本机制,并重点介绍与该主题相关的最新发现。
Itch is a universally experienced sensation, and chronic itch can be as diabolically debilitating as pain. Recent advances have not only identified the neuronal itch sensing circuitry, but also have uncovered the intricate interactions between skin and immune cells that work together with neurons to identify itch-inducing irritants. In this review, we will summarize the fundamental mechanisms of acute itch detection in the skin, as well as highlight the recent discoveries relating to this topic.
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