Particle-based methods for multiscale modeling of blood flow in the circulation and in devices: challenges and future directions. Sixth International Bio-Fluid Mechanics Symposium and Workshop March 28-30, 2008 Pasadena, California.
Particle-based methods for multiscale modeling of blood flow in the circulation and in devices: challenges and future directions. Sixth International Bio-Fluid Mechanics Symposium and Workshop March 28-30, 2008 Pasadena, California.
复制标题
DOI：
10.1007/s10439-010-9904-x
复制
发表时间：
2010-03
影响因子：
3.8
通讯作者：
Bluestein, Danny
中科院分区：
文献类型：
--
作者：
Yamaguchi, Takami;Ishikawa, Takuji;Imai, Y.;Matsuki, N.;Xenos, Mikhail;Deng, Yuefan;Bluestein, Danny
多尺度模拟的一个主要计算挑战是分子力学和宏观输运之间不同的长度和时间尺度的耦合，跨越时空尺度表征流动诱导的血液凝固中发生的复杂过程。流动和压力对类细胞血小板的影响可以用连续介质力学模型很好地描述，这种模型可以精确到微米级。然而，黏附/聚集键的分子效应是纳米量级的。一个成功的多尺度血小板对设备中流动压力的反应模型以及随后的凝血反应应该能够表征凝血反应及其与流动的相互作用。本文试图描述近年来发展起来的一些计算方法，并提供给该领域的研究人员。它们不同于主导该领域的传统方法，通过扩展流行的基于连续统的方法，或者完全背离它们，产生一个扩展的工具包，可能有助于进一步阐明血流的潜在机制和细胞对血流的反应。我们提供了一种范式转变，采用了多学科方法，将流体动力学模拟与生物物理和生化运输相结合。
A major computational challenge for a multiscale modeling is the coupling of disparate length and timescales between molecular mechanics and macroscopic transport, spanning the spatial and temporal scales characterizing the complex processes taking place in flow-induced blood clotting. Flow and pressure effects on a cell-like platelet can be well represented by a continuum mechanics model down to the order of the micrometer level. However, the molecular effects of adhesion/aggregation bonds are on the order of nanometer. A successful multiscale model of platelet response to flow stresses in devices and the ensuing clotting responses should be able to characterize the clotting reactions and their interactions with the flow. This paper attempts to describe a few of the computational methods that were developed in recent years and became available to researchers in the field. They differ from traditional approaches that dominate the field by expanding on prevailing continuum-based approaches, or by completely departing from them, yielding an expanding toolkit that may facilitate further elucidation of the underlying mechanisms of blood flow and the cellular response to it. We offer a paradigm shift by adopting a multidisciplinary approach with fluid dynamics simulations coupled to biophysical and biochemical transport.
登录
查看更多内容
影响因子：
1.9
作者：
Hadjiconstantinou, NG;Patera, AT
通讯作者：
Patera, AT
影响因子：
2.2
作者：
Dzwinel, W;Yuen, DA;Boryczko, K
通讯作者：
Boryczko, K
影响因子：
6.3
作者：
BERENDSEN, HJC;VANDERSPOEL, D;VANDRUNEN, R
通讯作者：
VANDRUNEN, R
影响因子：
6.1
作者：
Boryczko, K;Dzwinel, W;Yuen, DA
通讯作者：
Yuen, DA
影响因子：
4.1
作者：
Deng, YF;Peierls, RF;Rivera, C
通讯作者：
Rivera, C