The incidence and survival rate of population-based pancreatic cancer patients: Shanghai Cancer Registry 2004-2009.
The incidence and survival rate of population-based pancreatic cancer patients: Shanghai Cancer Registry 2004-2009.
复制标题
DOI：
10.1371/journal.pone.0076052
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zhao N
中科院分区：
文献类型：
--
作者：
Luo J;Xiao L;Wu C;Zheng Y;Zhao N
胰腺癌是一种毁灭性的疾病，预后很差。在中国，缺乏关于其存活率及其影响因素的大量人群证据。本研究旨在描述中国市区胰腺癌患者的人口学因素、肿瘤特征、发病率和生存率。从上海市肿瘤登记中心收集2004-2009年所有确诊的胰腺癌病例的人口学因素、肿瘤特征。通过上海市肿瘤登记处和上海市生命统计登记处的联动，确定患者的生存时间。死亡证明的截止日期是2012年12月底。采用Kaplan-Meier法和Cox比例风险回归模型分析生存率及其影响因素。2004年至2009年，上海常住居民共确诊胰腺癌新发病例11672例。胰腺癌粗发病率从2004年的12.80/10万上升到2009年的15.66/10万，标化发病率约为6.70/10万，变化不大。5年生存率为4.1%，中位生存期为3.9个月(95%可信区间3.8~4.0个月)。接受手术切除的受试者的存活率(HR = 为0.742，95%CI：0.634-0.868)高于其受试者。在调整后的多变量Cox比例风险模型中，与生存不良相关的因素包括确诊时的高龄(年龄和GT； = 70年：危险比(HR) = 1.827，95%CI：1.614-2.067)，男性(HR = 1.155，95%CI：1.041-1.281)，确诊时远处疾病(HR = 1.257，95%CI：1.061-1.488)，阳性淋巴结(HR = 1.236，95%CI：1.085-1.408)，肿瘤分期(IV期HR = 2.817，95%可信区间：2.029-3.909)。上海市常住居民胰腺癌患者年龄调整发病率稳定，总体生存率低。需要及早发现和改进治疗策略，以改善这种致命疾病的预后。
Pancreatic cancer is a devastating disease with dismal prognosis. Large population-based evidence on its survival rate and influence factors is lacking in China. This study aimed to depict the demographic factors, tumor characteristics, incidence rate and survival rate of pancreatic cancer cases in urban China. The demographic factors, tumor characteristics were collected for all the pancreatic cancer cases identified during 2004 to 2009 from the Shanghai Cancer Registry. The survival time was ascertained through linkage of the Shanghai Cancer Registry and the Shanghai Vital Statistics Registry. The deadline of death certificates was the end of December 2012. Kaplan-Meier method and Cox proportional-hazards regression model were used to explore the survival rate and influence factors. 11,672 new pancreatic cancer cases were identified among Shanghai residency during 2004 to 2009. The crude incidence rate of pancreatic cancer was increasing from 12.80/100,000 in 2004 to 15.66/100,000 in 2009, while the standardized incidence rate was about 6.70/100,000 and didn't change a lot. The overall 5-year survival rate was 4.1% and the median survival time was 3.9 (95% Confidence Interval (CI) 3.8–4.0) months. Subjects had received surgical resection had improved survival (HR = 0.742, 95% CI: 0.634–0.868) than its counterparts. In adjusted multivariable Cox proportional-hazard models, factors associated with poor survival included older age at diagnosis (age > = 70 years: hazard ratio (HR) = 1.827, 95% CI: 1.614–2.067), male sex (HR = 1.155, 95% CI: 1.041–1.281), distant disease at diagnosis (HR = 1.257, 95% CI: 1.061–1.488), positive lymph node (HR = 1.236, 95% CI: 1.085–1.408), tumor stage (Stage IV HR = 2.817, 95% CI: 2.029–3.909). The age-adjusted incidence rate was stable and overall survival rate was low among pancreatic cancer patients of Shanghai residency. Early detection and improved treatment strategies are needed to improve prognosis for this deadly disease.
登录
查看更多内容
影响因子：
5.1
作者：
Chen, Wan-qing;Zeng, Hong-mei;He, Jie
通讯作者：
He, Jie
影响因子：
3
作者：
Eloubeidi, Mohamad A.;Desmond, Renee A.;Vickers, Selwyn M.
通讯作者：
Vickers, Selwyn M.
影响因子：
6.4
作者：
Ben, Qiwen;Wang, Kaixuan;Li, Zhaoshen
通讯作者：
Li, Zhaoshen
影响因子：
2.9
作者：
Takai, S;Satoi, S;Kamiyama, Y
通讯作者：
Kamiyama, Y
影响因子：
9
作者：
Lim, JE;Chien, MW;Earle, CC
通讯作者：
Earle, CC