The Association Between Impaired Awareness and Depression, Anxiety, and Apathy in Mild to Moderate Alzheimer's Disease: A Systematic Review.
The Association Between Impaired Awareness and Depression, Anxiety, and Apathy in Mild to Moderate Alzheimer's Disease: A Systematic Review.
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DOI：
10.3389/fpsyt.2021.633081
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发表时间：
2021
影响因子：
4.7
通讯作者：
Huntley J
中科院分区：
文献类型：
--
作者：
Azocar I;Livingston G;Huntley J
目的：认知和功能缺陷的意识障碍是阿尔茨海默病（AD）的常见特征。虽然缺乏意识被认为是一个保护因素，对经历情感症状，如抑郁，焦虑和冷漠，这是常见的AD，有相互矛盾的证据之间的联系。这篇系统性综述研究了轻度至中度AD患者意识受损与抑郁、焦虑和冷漠症状之间相关性的证据。方法：我们检索了四个数据库（OvidMedline、Embase、PsycInfo和PsycArticles），使用的术语包括意识、冷漠、抑郁、焦虑和轻中度AD。我们纳入了评估意识与抑郁症状、焦虑症状或冷漠之间关系的研究。我们评估了纳入论文的质量，并使用叙述方法报告结果，优先考虑高质量的研究。结果：我们确定了1，544篇文章，27项研究符合纳入标准（高质量= 15;中等质量= 12）。大多数高质量的研究报告说，早期AD的意识受损与较少的抑郁症状和焦虑症状（相关性范围从-0.3到-0.7），但更多的冷漠。结论：高质量的研究表明，在早期AD患者中，意识受损与更少的抑郁和焦虑症状以及更多的冷漠有关。未来的研究应该集中在阐明AD患者意识受损和这些症状之间的因果关系上。
Objectives: Impaired awareness of cognitive and functional deficits is a common feature of Alzheimer's disease (AD). Although a lack of awareness has been suggested to be a protective factor against experiencing affective symptoms, such as depression, anxiety, and apathy which are common in AD, there is conflicting evidence about the links between them. This systematic review examines the evidence for an association between impaired awareness and depressive, anxiety, and apathy symptoms in mild to moderate AD. Method: We searched four databases (OvidMedline, Embase, PsycInfo, and PsycArticles) using terms encompassing awareness, apathy, depression, anxiety, and mild-moderate AD. We included studies that assessed the relationship between awareness and depressive symptoms, anxiety symptoms, or apathy. We assessed included papers for quality and report results using a narrative approach, prioritizing high quality studies. Results: We identified 1,544 articles, and twenty-seven studies fulfilled inclusion criteria (high-quality = 15; moderate-quality = 12). Most high-quality studies reported that impaired awareness in early-stage AD is cross-sectionally linked with fewer depressive symptoms and anxiety symptoms (correlation ranged from −0.3 to −0.7), but with more apathy. Conclusions: High-quality studies suggested that in people with early AD, impaired awareness is related to fewer depressive and anxiety symptoms and to more apathy. Future research should focus on elucidating causality among impaired awareness and these symptoms in AD.
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影响因子：
48
作者：
Kalaria, Raj N.;Maestre, Gladys E.;Arizaga, Raul;Friedland, Robert P.;Galasko, Doug;Hall, Kathleen;Luchsinger, Jose A.;Ogunniyi, Adesola;Perry, Elaine K.;Potocnik, Felix;Prince, Martin;Stewart, Robert;Wimo, Anders;Zhang, Zhen-Xin;Antuono, Piero
通讯作者：
Antuono, Piero
DOI：
10.1080/01688639008400980
发表时间：
1990-03-01
影响因子：
2.2
作者：
DEBETTIGNIES, BH;MAHURIN, RK;PIROZZOLO, FJ
通讯作者：
PIROZZOLO, FJ
影响因子：
7
作者：
Lehrner, Johann;Kogler, Sandra;Auff, Eduard
通讯作者：
Auff, Eduard
影响因子：
4
作者：
Conde-Sala, Josep L.;Rene-Ramirez, Ramon;Garre-Olmo, Josep
通讯作者：
Garre-Olmo, Josep
影响因子：
4
作者：
Horning, Sheena M.;Melrose, Rebecca;Sultzer, David
通讯作者：
Sultzer, David