Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Values Predict the Development of Hepatocellular Carcinoma among Patients with Chronic Hepatitis C after Sustained Virological Response.
Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Values Predict the Development of Hepatocellular Carcinoma among Patients with Chronic Hepatitis C after Sustained Virological Response.
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DOI：
10.1371/journal.pone.0129053
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Yatsuhashi H
中科院分区：
文献类型：
--
作者：
Sasaki R;Yamasaki K;Abiru S;Komori A;Nagaoka S;Saeki A;Hashimoto S;Bekki S;Kugiyama Y;Kuno A;Korenaga M;Togayachi A;Ocho M;Mizokami M;Narimatsu H;Ichikawa T;Nakao K;Yatsuhashi H
血清中紫藤凝集素阳性人 Mac-2 结合蛋白 (WFA+-M2BP) 的测量最近被证明是评估肝纤维化的无创方法。本研究的目的是评估血清 WFA+-M2BP 值在预测通过干扰素治疗获得持续病毒学应答 (SVR) 的患者肝细胞癌 (HCC) 发展方面的效用。为此，我们回顾性分析了我科接受干扰素治疗的238例SVR患者。在治疗前（Tx 前）、治疗后（干扰素完成后 24 周；Tx 后）、HCC 诊断时间和最后一次临床就诊时测量血清 WFA+-M2BP 值。在 238 名 SVR 患者中，16 名 (6.8%) 患者发展为 HCC。平均随访期为 9.1 年。 HCC 5 年累计发病率为 3.4%，10 年累计发病率为 7.5%。 Tx 前和 Tx 后 WFA+-M2BP 中位值分别为 1.69（范围：0.28 至 12.04 截止指数 (COI)）和 0.80（范围：0.17 至 5.29 COI）。 SVR 后 WFA+-M2BP 值显着下降（P < 0.001）。发生 HCC 的患者的 Tx 后 WFA+-M2BP 中位值显着高于未发生 HCC 的患者 (P < 0.01)。多变量分析显示，年龄（> 60岁）、性别（男性）、Tx前血小板计数（< 15.0×103/μL）和Tx后WFA+-M2BP（> 2.0 COI）与SVR后HCC的发生相关。 Tx 后 WFA+-M2BP (> 2.0 COI) 与 SVR 患者发生 HCC 的风险相关。 WFA+-M2BP 值可能是 SVR 后 HCC 的新预测因子。
Measurement of Wisteria floribunda agglutinin-positive human Mac-2 binding protein (WFA+-M2BP) in serum was recently shown to be a noninvasive method to assess liver fibrosis. The aim of this study was to evaluate the utility of serum WFA+-M2BP values to predict the development of hepatocellular carcinoma (HCC) in patients who achieved a sustained virological response (SVR) by interferon treatment. For this purpose, we retrospectively analyzed 238 patients with SVR who were treated with interferon in our department. Serum WFA+-M2BP values were measured at pre-treatment (pre-Tx), post-treatment (24 weeks after completion of interferon; post-Tx), the time of HCC diagnosis, and the last clinical visit. Of 238 patients with SVR, HCC developed in 16 (6.8%) patients. The average follow-up period was 9.1 years. The cumulative incidence of HCC was 3.4% at 5 years and 7.5% at 10 years. The median pre-Tx and post-Tx WFA+-M2BP values were 1.69 (range: 0.28 to 12.04 cutoff index (COI)) and 0.80 (range: 0.17 to 5.29 COI), respectively. The WFA+-M2BP values decreased significantly after SVR (P < 0.001). The median post-Tx WFA+-M2BP value in patients who developed HCC was significantly higher than that in patients who did not (P < 0.01). Multivariate analysis disclosed that age (> 60 years), sex (male), pre-Tx platelet count (< 15.0×103/μL), and post-Tx WFA+-M2BP (> 2.0 COI) were associated with the development of HCC after SVR. Post-Tx WFA+-M2BP (> 2.0 COI) is associated with the risk for development of HCC among patients with SVR. The WFA+-M2BP values could be a new predictor for HCC after SVR.
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影响因子：
2
作者：
Kuno, Atsushi;Sato, Takashi;Narimatsu, Hisashi
通讯作者：
Narimatsu, Hisashi
影响因子：
2.5
作者：
Cheung, K. J.;Tilleman, K.;Van Vlierberghe, H.
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Van Vlierberghe, H.
影响因子：
6.2
作者：
Makiyama, A;Itoh, Y;Okanoue, T
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Okanoue, T
影响因子：
12.6
作者：
Backus, Lisa I.;Boothroyd, Derek B.;Mole, Larry A.
通讯作者：
Mole, Larry A.
影响因子：
6.3
作者：
Ikeda, M;Fujiyama, S;Watanabe, H
通讯作者：
Watanabe, H