Is it time to screen for the haptoglobin genotype to assess the cardiovascular risk profile and vitamin E therapy responsiveness in patients with diabetes?
Is it time to screen for the haptoglobin genotype to assess the cardiovascular risk profile and vitamin E therapy responsiveness in patients with diabetes?
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是时候筛选抗乳清球蛋白基因型来评估糖尿病患者的心血管风险特征和维生素E治疗反应能力吗？
DOI：
10.1007/s11892-012-0265-8
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发表时间：
2012-06
影响因子：
4.2
通讯作者：
Levy, Andrew P.
中科院分区：
文献类型：
--
作者：
Vardi, Moshe;Levy, Andrew P.
糖尿病（DM）增加了心血管并发症的风险。结合珠蛋白（Hp）是一种丰富的血浆蛋白，由于其能够阻断体外血红蛋白的氧化活性而具有抗氧化功能。在Hp基因座上存在两个共同的功能等位基因，记为1和2，具有三种Hp基因型（Hp 1-1、2-1和2-2）。在Hp 2-2个体中表达的Hp蛋白在保护免受血红蛋白诱导的氧化应激方面明显较差。Hp 2-2型糖尿病患者发生糖尿病并发症的风险增加，特别是糖尿病心血管疾病（CVD）。本文综述了Hp基因型和DM对CVD影响的生物学机制，以及越来越多的证据支持对所有DM患者进行Hp基因分型，并为Hp 2-2 DM患者提供抗氧化维生素E补充剂，以降低其CVD发病率和死亡率。
Diabetes mellitus (DM) carries an increased risk for cardiovascular complications. Haptoglobin (Hp) is an abundant plasma protein with an anti-oxidant function by virtue of its ability to block the oxidative activity of extracorposcular hemoglobin. There exist two common functional alleles at the Hp genetic locus, denoted 1 and 2, with three Hp genotypes (Hp 1-1, 2-1 and 2-2). The Hp protein expressed in Hp 2-2 individuals is markedly inferior in protecting against hemoglobin induced oxidative stress. Hp 2-2 DM individuals have been shown to be at increased risk for the development of diabetes complications, particularly diabetic cardiovascular disease (CVD). We review here the biological mechanisms underlying the interaction between the Hp genotype and DM on CVD and the accumulating evidence in favor of Hp genotyping all individuals with DM and providing antioxidant vitamin E supplementation specifically to Hp 2-2 DM individuals in order to reduce their CVD morbidity and mortality.
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影响因子：
7.7
作者：
Asleh R;Blum S;Kalet-Litman S;Alshiek J;Miller-Lotan R;Asaf R;Rock W;Aviram M;Milman U;Shapira C;Abassi Z;Levy AP
通讯作者：
Levy AP
DOI：
10.1056/nejmoa1001282
发表时间：
2010-04-29
期刊：
The New England journal of medicine
影响因子：
--
作者：
ACCORD Study Group;Ginsberg HN;Elam MB;Lovato LC;Crouse JR 3rd;Leiter LA;Linz P;Friedewald WT;Buse JB;Gerstein HC;Probstfield J;Grimm RH;Ismail-Beigi F;Bigger JT;Goff DC Jr;Cushman WC;Simons-Morton DG;Byington RP
通讯作者：
Byington RP
影响因子：
7.7
作者：
Costacou, Tina;Ferrell, Robert E.;Orchard, Trevor J.
通讯作者：
Orchard, Trevor J.
影响因子：
4.8
作者：
FACTOR, SM;MINASE, T;SONNENBLICK, EH
通讯作者：
SONNENBLICK, EH
影响因子：
16.2
作者：
King, H;Aubert, RE;Herman, WH
通讯作者：
Herman, WH