Expression of fox-related genes in the skin follicles of Inner Mongolia cashmere goat.
Expression of fox-related genes in the skin follicles of Inner Mongolia cashmere goat.
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狐狸相关基因在内蒙古绒山羊皮毛囊中的表达
DOI：
10.5713/ajas.17.0115
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Han W;Li X;Wang L;Wang H;Yang K;Wang Z;Wang R;Su R;Liu Z;Zhao Y;Zhang Y;Li J
目的研究绒山羊胚胎发育不同时期基因的表达。方法利用生物信息学方法对内蒙古绒山羊45、55、65日龄胎儿皮肤组织进行转录组测序分析。结果Fox基因家族中的FoxN1、FoxE1和FoxI3基因可能参与毛囊的生长发育和毛发的形成，这与前人的研究结果一致。采用实时荧光定量聚合酶链反应检测系统和Western blot分析方法，对绒山羊胎儿和成年个体体部皮肤中FoxN1、FoxE1和FoxI3基因的相对差异表达进行了研究。结论本研究为进一步研究毛囊发育相关基因及其在毛囊发生、生长和发育中的作用提供了新的基础信息。
Objective This study investigated the expression of genes in cashmere goats at different periods of their fetal development. Methods Bioinformatics analysis was used to evaluate data obtained by transcriptome sequencing of fetus skin samples collected from Inner Mongolia cashmere goats on days 45, 55, and 65 of fetal age. Results We found that FoxN1, FoxE1, and FoxI3 genes of the Fox gene family were probably involved in the growth and development of the follicle and the formation of hair, which is consistent with previous findings. Real-time quantitative polymerase chain reaction detecting system and Western blot analysis were employed to study the relative differentially expressed genes FoxN1, FoxE1, and FoxI3 in the body skin of cashmere goat fetuses and adult individuals. Conclusion This study provided new fundamental information for further investigation of the genes related to follicle development and exploration of their roles in hair follicle initiation, growth, and development.
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DOI：
10.1002/stem.2363
发表时间：
2016-07
期刊：
Stem cells (Dayton, Ohio)
影响因子：
--
作者：
Shirokova V;Biggs LC;Jussila M;Ohyama T;Groves AK;Mikkola ML
通讯作者：
Mikkola ML
影响因子：
2.7
作者：
Prowse, DM;Lee, D;Brissette, JL
通讯作者：
Brissette, JL
影响因子：
4
作者：
Alonso, L;Fuchs, E
通讯作者：
Fuchs, E
影响因子：
11.4
作者：
HARDY, MH
通讯作者：
HARDY, MH
影响因子：
64.5
作者：
Weiner, Lorin;Han, Rong;Brissette, Janice L.
通讯作者：
Brissette, Janice L.