Subregional Differences in Alcohol Modulation of Central Amygdala Neurocircuitry.
Subregional Differences in Alcohol Modulation of Central Amygdala Neurocircuitry.
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DOI：
10.3389/fnmol.2022.888345
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发表时间：
2022
影响因子：
4.8
通讯作者：
Silberman Y
中科院分区：
文献类型：
--
作者：
Melkumyan M;Silberman Y
酒精使用障碍是一种非常重要的医学状况，其特征是停止或控制酒精使用的能力受损，强迫性酒精寻求行为和缺乏酒精时的戒断症状。了解酒精如何调节对长期酗酒至关重要的神经回路，如中央杏仁核（CeA），可能会导致治疗酒精使用障碍的新治疗策略的发展。在临床研究中，杏仁核体积的减少与酒精复发的易感性有关。临床前研究表明，CeA参与了酒精使用的影响，杏仁核病变显示饮酒减少，CeA细胞的操作改变了饮酒。大量的研究表明，急性酒精和慢性酒精暴露通过摄入或依赖模型，改变了谷氨酸能和gaba能在CeA中的传递。然而，CeA包含异质细胞群和神经回路结构的明显分区域差异，这可能影响酒精调节CeA功能的机制。本综述旨在分析酒精对CeA内侧亚区和外侧亚区影响的差异，以及神经炎症细胞和标志物、内源性大麻素系统和最常研究的神经肽系统在介导这些影响中所起的作用。更好地了解酒精对CeA分区域细胞类型和神经回路功能的影响，可能会导致更多选择性药物干预酒精使用障碍的发展。
Alcohol use disorder is a highly significant medical condition characterized by an impaired ability to stop or control alcohol use, compulsive alcohol seeking behavior, and withdrawal symptoms in the absence of alcohol. Understanding how alcohol modulates neurocircuitry critical for long term and binge-like alcohol use, such as the central amygdala (CeA), may lead to the development of novel therapeutic strategies to treat alcohol use disorder. In clinical studies, reduction in the volume of the amygdala has been linked with susceptibility to relapse to alcohol use. Preclinical studies have shown the involvement of the CeA in the effects of alcohol use, with lesions of the amygdala showing a reduction in alcohol drinking, and manipulations of cells in the CeA altering alcohol drinking. A great deal of work has shown that acute alcohol, as well as chronic alcohol exposure via intake or dependence models, alters glutamatergic and GABAergic transmission in the CeA. The CeA, however, contains heterogeneous cell populations and distinct subregional differences in neurocircuit architecture which may influence the mechanism by which alcohol modulates CeA function overall. The current review aimed to parse out the differences in alcohol effects on the medial and lateral subregions of the CeA, and what role neuroinflammatory cells and markers, the endocannabinoid system, and the most commonly studied neuropeptide systems play in mediating these effects. A better understanding of alcohol effects on CeA subregional cell type and neurocircuit function may lead to development of more selective pharmacological interventions for alcohol use disorder.
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影响因子：
12.8
作者：
Babaev O;Piletti Chatain C;Krueger-Burg D
通讯作者：
Krueger-Burg D
影响因子：
5.3
作者：
Ciccocioppo, Roberto;de Guglielmo, Giordano;Roberto, Marisa
通讯作者：
Roberto, Marisa
影响因子：
2.8
作者：
Colombo, G;Serra, S;Gessa, GL
通讯作者：
Gessa, GL
DOI：
10.1073/pnas.0802302105
发表时间：
2008-06-17
影响因子：
11.1
作者：
Bajo, Michal;Cruz, Maureen T.;Roberto, Marisa
通讯作者：
Roberto, Marisa
影响因子：
7.6
作者：
Blednov, Yuri A.;Cravatt, Benjamin F.;Harris, R. Adron
通讯作者：
Harris, R. Adron