Identifying target areas for risk-based surveillance and control of transboundary animal diseases: a seasonal analysis of slaughter and live-trade cattle movements in Uganda.
Identifying target areas for risk-based surveillance and control of transboundary animal diseases: a seasonal analysis of slaughter and live-trade cattle movements in Uganda.
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DOI：
10.1038/s41598-023-44518-4
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发表时间：
2023-10-30
影响因子：
4.6
通讯作者：
Bronsvoort, Barend Mark de C.
中科院分区：
文献类型：
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作者：
Gonzalez-Gordon, Lina;Porphyre, Thibaud;Muwonge, Adrian;Nantima, Noelina;Ademun, Rose;Ochwo, Sylvester;Mwiine, Norbert Frank;Boden, Lisa;Muhanguzi, Dennis;Bronsvoort, Barend Mark de C.
动物流动是跨界动物疾病传播的主要驱动因素。这些流动将原本孤立的人口联系在一起，从而为易感和受感染的个人创造了相遇的机会。我们使用社会网络分析来描述乌干达牛只运动的季节性网络结构，并揭示关键的网络特征，以确定有针对性的基于风险的监测和干预的地区或次区域。我们使用官方牲畜流动数据，基于2019年地区间牛的流动构建了加权定向网络；运动的目的（“屠宰”与“现场交易”）用于对网络进行子集划分，并更可靠地捕捉风险。我们的研究结果表明，牛交易可能导致乌干达本地和远距离疾病传播。季节变化似乎会影响网络的结构，节点和边缘活动在整个季节都具有高度异质性。这些观察结果意味着，可以利用活体贸易网络的结构来瞄准牛走廊内有影响力的区域中心以及南部和西部的外围地区，这将导致网络迅速碎片化，减少与接触结构相关的贸易风险。在屠宰网络中也观察到类似的可开发特征，在那里，牛交通主要服务于沿着牛走廊靠近城市中心的屠宰中心。至关重要的是，针对复杂的牲畜供应链价值链的分析提供了一个独特的框架，可以理解和量化像乌干达这样的内陆国家的口蹄疫等TADs风险。这些发现可用于为基于风险的监测战略的制定和资源分配决策提供信息。例如，疫苗部署、生物安全执法以及地方社区和整个动物卫生服务部门利益攸关方的能力建设，有可能限制疫情的社会经济影响，或确实减少其频率。
Animal movements are a major driver for the spread of Transboundary Animal Diseases (TADs). These movements link populations that would otherwise be isolated and hence create opportunities for susceptible and infected individuals to meet. We used social network analysis to describe the seasonal network structure of cattle movements in Uganda and unravel critical network features that identify districts or sub-regions for targeted risk-based surveillance and intervention. We constructed weighted, directed networks based on 2019 between-district cattle movements using official livestock mobility data; the purpose of the movement (‘slaughter’ vs. ‘live trade’) was used to subset the network and capture the risks more reliably. Our results show that cattle trade can result in local and long-distance disease spread in Uganda. Seasonal variability appears to impact the structure of the network, with high heterogeneity of node and edge activity identified throughout the seasons. These observations mean that the structure of the live trade network can be exploited to target influential district hubs within the cattle corridor and peripheral areas in the south and west, which would result in rapid network fragmentation, reducing the contact structure-related trade risks. Similar exploitable features were observed for the slaughter network, where cattle traffic serves mainly slaughter hubs close to urban centres along the cattle corridor. Critically, analyses that target the complex livestock supply value chain offer a unique framework for understanding and quantifying risks for TADs such as Foot-and-Mouth disease in a land-locked country like Uganda. These findings can be used to inform the development of risk-based surveillance strategies and decision making on resource allocation. For instance, vaccine deployment, biosecurity enforcement and capacity building for stakeholders at the local community and across animal health services with the potential to limit the socio-economic impact of outbreaks, or indeed reduce their frequency.
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影响因子：
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作者：
Muwonge, Adrian;Wee, Bryan A.;Mugerwa, Ibrahimm;Nabunya, Emma;Mpyangu, Christine M.;Bronsvoort, Barend M. de C.;Ssebaggala, Emmanuel Robert;Kiayias, Aggelos;Mwaka, Erisa;Joloba, Moses
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Joloba, Moses
影响因子：
3.7
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Humphries MD;Gurney K
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Gurney K
影响因子：
3.7
作者：
Munsey, Anna;Mwiine, Frank Norbert;Ochwo, Sylvester;Velazquez-Salinas, Lauro;Ahmed, Zaheer;Rodriguez, Luis L.;Rieder, Elizabeth;Perez, Andres;VanderWaal, Kimberly
通讯作者：
VanderWaal, Kimberly
影响因子：
3.2
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影响因子：
2.6
作者：
Chenais, Erika;Lewerin, Susanna Sternberg;Emanuelson, Ulf
通讯作者：
Emanuelson, Ulf