Ecological and Anthropogenic Spatial Gradients Shape Patterns of Dispersal of Foot-and-Mouth Disease Virus in Uganda.
Ecological and Anthropogenic Spatial Gradients Shape Patterns of Dispersal of Foot-and-Mouth Disease Virus in Uganda.
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DOI：
10.3390/pathogens11050524
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发表时间：
2022-04-29
期刊：
影响因子：
3.7
通讯作者：
VanderWaal, Kimberly
中科院分区：
文献类型：
--
作者：
Munsey, Anna;Mwiine, Frank Norbert;Ochwo, Sylvester;Velazquez-Salinas, Lauro;Ahmed, Zaheer;Rodriguez, Luis L.;Rieder, Elizabeth;Perez, Andres;VanderWaal, Kimberly
利用地理参照系统发育树，生态地理学使研究人员能够阐明环境异质性和传染病传播模式之间的相互作用。随着病原体基因序列数据的日益可用，越来越需要测试这一领域流行病学假设的工具。在这项研究中，我们应用传统上用于生态学的工具来阐明口蹄疫病毒（FMDV）在乌干达的流行病学。我们从牛的横断面研究中分析了O型口蹄疫病毒的基因序列及其相应的时空元数据。我们应用步骤选择函数（SSF）模型，通常用于研究野生动物栖息地的选择，病毒的繁殖，表明口蹄疫病毒更有可能被发现在降雨量低的地区。接下来，我们使用一种新的方法，资源梯度函数（RGF）模型，阐明病毒源和汇区的特点。应用于我们的数据的RGF模型显示，高密度的牛和牲畜市场附近的地区可能作为口蹄疫病毒在乌干达传播的来源，和降雨量低的地区作为病毒的水槽，经验丰富的重新引入。我们的研究结果可能有助于为乌干达基于风险的FMDV控制策略提供信息。更广泛地说，这些工具推进了系统发育工具包，因为它们可能有助于揭示存在基因序列和相应时空元数据的其他生物的传播模式。
Using georeferenced phylogenetic trees, phylogeography allows researchers to elucidate interactions between environmental heterogeneities and patterns of infectious disease spread. Concordant with the increasing availability of pathogen genetic sequence data, there is a growing need for tools to test epidemiological hypotheses in this field. In this study, we apply tools traditionally used in ecology to elucidate the epidemiology of foot-and-mouth disease virus (FMDV) in Uganda. We analyze FMDV serotype O genetic sequences and their corresponding spatiotemporal metadata from a cross-sectional study of cattle. We apply step selection function (SSF) models, typically used to study wildlife habitat selection, to viral phylogenies to show that FMDV is more likely to be found in areas of low rainfall. Next, we use a novel approach, a resource gradient function (RGF) model, to elucidate characteristics of viral source and sink areas. An RGF model applied to our data reveals that areas of high cattle density and areas near livestock markets may serve as sources of FMDV dissemination in Uganda, and areas of low rainfall serve as viral sinks that experience frequent reintroductions. Our results may help to inform risk-based FMDV control strategies in Uganda. More broadly, these tools advance the phylogenetic toolkit, as they may help to uncover patterns of spread of other organisms for which genetic sequences and corresponding spatiotemporal metadata exist.
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