Childhood familial and racial differences in physiologic and biochemical factors related to hypertension.
Childhood familial and racial differences in physiologic and biochemical factors related to hypertension.
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与高血压相关的生理生化因素的童年家族和种族差异。
DOI：
10.1161/01.hyp.5.1.56
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Braunstein,ML
中科院分区：
文献类型：
--
作者：
Hohn,AR;Riopel,DA;Keil,JE;Loadholt,CB;Margolius,HS;Halushka,PV;Privitera,PJ;Webb,JG;Medley,ES;Schuman,SH;Rubin,MI;Pantell,RH;Braunstein,ML
在10-17岁血压正常的儿童中，寻找高血压和血压正常的父母的后代之间血流动力学变量和血管活性物质的早期差异。42名高血压父母的黑人和34名白色儿童（病例）和年龄平衡的20名黑人和45名正常血压父母的白色儿童（对照）进行了运动负荷试验。血压，心率，尿电解质，激肽释放酶，前列腺素E样物质，血浆肾素活性和去甲肾上腺素进行测量之前，期间和之后的运动。分析比较了四个受试者组的结果：黑人病例与黑人对照，白色病例与白色对照，黑人病例与白色病例，黑人对照与白色对照。根据高血压家族史，发现了显着的家族差异：黑人病例“更大”（p= 0.003），且静息收缩压、舒张压和最大运动舒张压较高，运动后血浆肾素活性较高（p= 0.04）;与白色对照组相比，白色病例也较大（p= 0.004），运动后心率较高，运动前尿前列腺素E样物质较高，运动后血浆去甲肾上腺素较低（p< 0.05）。在心率、血压、尿电解质和其他生化物质方面存在显著的种族差异。在这些病例中，黑人/白色人的比较显示，黑人运动后心率较低，静息和最大运动收缩压和舒张压较高（这些比较p< 0.04）。此外，黑人运动前尿钠排泄量较高，运动前尿钾排泄量较低（p< 0.003），运动前后血浆肾素活性较低（p< 0.003）。最后，黑人运动前后尿激肽释放酶排泄量较低（p< 0.03）。虽然黑人和白色对照组的血压相似，但比较显示，黑人运动前的钠和钾排泄量较高（p< 0.005），所有活动水平的血浆肾素活性较低，运动后10分钟血浆去甲肾上腺素较低（p< 0.05）。因此，在根据高血压家族史分类的血压正常儿童中，发现了被认为与高血压疾病发展相关的生理和生化变量的显著种族内和种族间差异。使用这些变量，黑人病例儿童可以从其他三个群体中分离出来，并且可能增加了成人发病高血压的风险。（高血压5：56-70，1983）
Early differences in hemodynamic variables and vasoactive substances between progeny of hypertensive and normotensive parents were sought in normotensive children aged 10-17 years. Forty-two black and 34 white children of hypertensive parents (cases) and an age-balanced group of 20 black and 45 white children of normotensive parents (controls) underwent exercise stress testing. Blood pressure, heart rate, urinary electrolytes, kallikrein, and prostaglandin E-like material, plasma renin activity, and norepinephrine were measured before, during, and after exercise. Analyses compared the findings of four subject groups: black cases with black controls, white cases with white controls, black cases with white cases, black controls with white controls. Based on a family history of hypertension, significant familial differences were found: Black cases" were larger"(p= 0.003) when compared to black control subjects and had higher resting systolic, dlastolic, and maximum exercise diastolic blood pressures, and higher postexercise plasma renin activity (p= 0.04); white cases also were larger (p= 0.004) in comparison with white controls and had higher postexercise heart rates, higher preexercise urinary prostaglandin E-like material, and lower plasma norepinephrine after exercise (p< 0.05). Significant racial differences were noted in heart rate, blood pressure, urinary electrolytes, and other biochemical substances. Among the cases, black/white comparisons showed that blacks had lower postexercise heart rates, and higher resting and maximum exercise systolic and diastolic blood pressures (p< 0.04 for these comparisons). Additionally, blacks had higher preexercise urinary sodium excretion, lower preexercise urinary potassium excretion (p< 0.003), and lower plasma renin activity before and after exercise (p< 0.003). Finally, urinary kallikrein excretion before and after exercise was lower in blacks (p< 0.03). While blood pressures were similar among the black and the white controls, comparisons revealed that the blacks had higher preexercise sodium and potassium excretion (p< 0.005), lower plasma renin activity at all levels of activity, and lower plasma norepinephrine 10 minutes after exercise (p< 0.05). Thus, significant intraracial and interracial differences in physiological and biochemical variables, thought to be related to the development of hypertensive diseases, have been detected in normotensive children categorized according to a family history of hypertension. With use of these variables, the black case children can be separated from the other three groups and may have increased risk for the development of adult onset hypertension.(Hypertension 5: 56-70, 1983)
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组织和血浆中去甲肾上腺素的灵敏放射性酶测定。
影响因子：
6.1
作者：
David P. Henry;B. Starman;David Johnson;Robert H. Williams
通讯作者：
Robert H. Williams
影响因子：
2.5
作者：
J. Mcdonough;G. E. Garrisox;C. Hames;R. Preston;Z. Schwartz;Y. Henley;Z. Zeit
通讯作者：
Z. Zeit
影响因子：
37.8
作者：
S. Zinner;H. Margolius;B. Rosner;E. Kass
通讯作者：
S. Zinner;H. Margolius;B. Rosner;E. Kass
影响因子：
2.6
作者：
Stevo Julius
通讯作者：
Stevo Julius
DOI：
10.1016/s0022-3476(78)80640-4
发表时间：
1978
期刊：
The Journal of pediatrics
影响因子：
--
作者：
A. North
通讯作者：
A. North