Sex differences in white matter alterations following repetitive subconcussive head impacts in collegiate ice hockey players.
Sex differences in white matter alterations following repetitive subconcussive head impacts in collegiate ice hockey players.
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DOI：
10.1016/j.nicl.2017.11.020
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Koerte IK
中科院分区：
文献类型：
--
作者：
Sollmann N;Echlin PS;Schultz V;Viher PV;Lyall AE;Tripodis Y;Kaufmann D;Hartl E;Kinzel P;Forwell LA;Johnson AM;Skopelja EN;Lepage C;Bouix S;Pasternak O;Lin AP;Shenton ME;Koerte IK
Repetitive subconcussive head impacts (RSHI) may lead to structural, functional, and metabolic alterations of the brain. While differences between males and females have already been suggested following a concussion, whether there are sex differences following exposure to RSHI remains unknown. The aim of this study was to identify and to characterize sex differences following exposure to RSHI. Twenty-five collegiate ice hockey players (14 males and 11 females, 20.6 ± 2.0 years), all part of the Hockey Concussion Education Project (HCEP), underwent diffusion-weighted magnetic resonance imaging (dMRI) before and after the Canadian Interuniversity Sports (CIS) ice hockey season 2011–2012 and did not experience a concussion during the season. Whole-brain tract-based spatial statistics (TBSS) were used to compare pre- and postseason imaging in both sexes for fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). Pre- and postseason neurocognitive performance were assessed by the Immediate Post-Concussion Assessment and Cognitive Test (ImPACT). Significant differences between the sexes were primarily located within the superior longitudinal fasciculus (SLF), the internal capsule (IC), and the corona radiata (CR) of the right hemisphere (RH). In significant voxel clusters (p < 0.05), decreases in FA (absolute difference pre- vs. postseason: 0.0268) and increases in MD (0.0002), AD (0.00008), and RD (0.00005) were observed in females whereas males showed no significant changes. There was no significant correlation between the change in diffusion scalar measures over the course of the season and neurocognitive performance as evidenced from postseason ImPACT scores. The results of this study suggest sex differences in structural alterations following exposure to RSHI. Future studies need to investigate further the underlying mechanisms and association with exposure and clinical outcomes. This study explores sex differences following repetitive subconcussive head impacts. Decreases in FA were observed in females over the course of one ice hockey season. Females also showed increases in MD, AD, and RD over the course of the season. In contrast, males showed no significant changes in these diffusion measures. The results suggest sex differences in structural alterations following subconcussion.
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影响因子：
4.1
作者：
Echlin, Paul S.;Johnson, Andrew M.;Forwell, Lorie A.
通讯作者：
Forwell, Lorie A.
影响因子：
4.2
作者：
Djebaili, M;Guo, QM;Stein, DG
通讯作者：
Stein, DG
影响因子：
4.8
作者：
Colvin, Alexis Chiang;Mullen, Jimmy;Groh, Megan
通讯作者：
Groh, Megan
影响因子：
1.6
作者：
Baker, John G.;Leddy, John J.;Willer, Barry S.
通讯作者：
Willer, Barry S.
影响因子：
11.3
作者：
ANDREASON, PJ;ZAMETKIN, AJ;COHEN, RM
通讯作者：
COHEN, RM